Human IL-3 recombinant Protein
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IL3, IL-3, MCGF, MULTI-CSF
Description of Human IL-3
Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues. It is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine.
The ED50 of ≤ 0.5ng/ml was determined by the dose-dependent stimulation of the proliferation of TF-1 cells. It corresponds to a specific activity of ≥ 2 x 106 units/mg.
The lyophilized IL-3 should be reconstituted in water to a concentration not less than 100µg/ml. This solution can be diluted into other buffered solutions or stored at -20 °C for future use.
Amino Acid Sequence
MAPMTQTTPL KTSWVNCSNM IDEIITHLKQ PPLPLLDFNN LNGEDQDILM ENNLRRPNLE AFNRAVKSLQ NASAIESILK NLLPCLPLAT AAPTRHPIHI KDGDWNEFRR KLTFYLKTLE NAQAQQTTLS LAIF
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