Human IL-4, cct-premium (HSA) recombinant Protein
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Phone: +49 (0) 40 . 43 20 84 48 0
E-Mail: info@active-bioscience.de
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Protein Synonyms: IL4, BSF1, IL-4, BCGF1, BSF-1, BCGF-1 Source: E. coli Purity: ≥ 98 % (SDS-PAGE, silver stained) Physical state: Lyophilized Manufacturer: |
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Active Bioscience
Product Details
Synonyms
IL4, BSF1, IL-4, BCGF1, BSF-1, BCGF-1
Description of Human IL-4, cct-premium (HSA)
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 130 amino acid residues
Biological Activity
The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is 0.1-0.5ng/ml.
Reconstitution
The lyophilized IL-4 should be reconstituted in water to a concentration not less than 100µg/ml. This solution can be diluted into other buffered solutions or stored at -20 °C for future use.
Amino Acid Sequence
MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
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