Human Immunoglobulin A (IgA)

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Product Overview, Sizes and Prices
	Proteins Synonyms: IgA Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 100 mM Tris-HCl, pH 8.0, with 100 mM NaCl and 0.05% NaN3. Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-090701-1MG 1 mg 90 € 16-16-090701-10MG 10 mg 630 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

IgA

 

Description of Human Immunoglobulin A (IgA)

Human Immunoglobulin A (IgA) is a 160 kDa protein. Serum immunoglobulin A (IgA) constitutes the second most abundant antibody class in human plasma (0.4–2.2 mg/mL), existing predominantly as monomeric IgA1 (80%) with lesser IgA2 contributions. Unlike secretory IgA-a dimeric mucosal protector featuring J-chains and a secretory component-serum IgA engages FcαRI (CD89) on myeloid cells to orchestrate systemic immunity. Monomeric serum IgA suppresses inflammation via inhibitory ITAMi signaling, while immune complexes activate phagocytosis, cytokine release, and antibody-dependent cellular cytotoxicity, balancing pathogen clearance and tissue homeostasis. Dysregulation of serum IgA underpins multiple pathologies. Selective IgA deficiency (sIgAD), the most common primary immunodeficiency, elevates risks for recurrent infections and autoimmune disorders like systemic lupus erythematosus (SLE) and celiac disease. Conversely, elevated serum IgA associates with IgA nephropathy, where galactose-deficient IgA1 deposits in renal glomeruli trigger complement-mediated inflammation and progressive kidney failure. Hyper-IgA levels may also signal immunodeficiency syndromes or multiple myeloma, particularly when beta-migrating monoclonal proteins complicate electrophoresis interpretation. The IgA2 subclass, distinguished by reduced sialylation, exhibits heightened pro-inflammatory activity linked to rheumatoid arthritis severity. Clinically, serum IgA quantification aids immunodeficiency diagnosis and myeloma monitoring, where nephelometric assays outperform traditional electrophoresis. Therapeutic strategies targeting FcαRI or aberrant IgA production, such as monoclonal antibodies against B-cell activating factor (BAFF), show promise in autoimmune and renal diseases. Additionally, engineered IgA antibodies are being explored for enhanced neutrophil-mediated tumor cytotoxicity, highlighting its expanding translational potential.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Immunoglobulin A (IgA) at ≤ -80°C.

 

Applications

In Vitro Diagnostic, Glycoproteomics, ELISA, Cancer, Chromatography Binding, Anaphalaxis, Infection, Autoimmune Diseases, Kidney Injury, Rheumatoid Arthritis.

 

Citations/Publications

Tsujita, Y., et al., (2018), 'A Severe Anaphylactic Reaction Associated with IgM-Class Anti-Human IgG Antibodies in a Hyper-IgM Syndrome Type 2 Patient', Journal of Clinical Immunology, 38: pp 144–148. Available at: https://doi.org/10.1007/s10875-017-0466-7
Abreu, R. B., et al., (2020), 'IgA Responses Following Recurrent Influenza Virus Vaccination.', Front. Immunol. 11: pp 902. Available at: doi: 10.3389/fimmu.2020.00902 
Chuzel, L., et al., (2021), 'Combining functional metagenomics and glycoanalytics to identify enzymes that facilitate structural characterization of sulfated N‐glycans', Microb Cell Fact, 20: pp 162. Available at: https://doi.org/10.1186/s12934-021-01652-w
Scarrone, M. et al., (2021), 'Development of anti-human IgM nanobodies as universal reagents for general immunodiagnostics', New BIOTECHNOLOGY 64: pp 9–16. Available at: https://doi.org/10.1016/j.nbt.2021.05.002
Frontera, E. D., et al., (2018), 'IgA Fc-folate conjugate activates and recruits neutrophils to directly target triple-negative breast cancer cells', Breast Cancer Research and Treatment 172: pp 551–560. Available at: https://doi.org/10.1007/s10549-018-4941-5

 

Shipped with dry ice

 

Gel Scan of Human Immunoglobulin A (IgA)

Fig. 1: SDS-PAGE Gel

 

 

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Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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