Human Immunoglobulin G Fc Fragment (IgG FC)

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Product Overview, Sizes and Prices
	Proteins Synonyms: IgG FC, Fc stands for "Fragment Constant region" or "Fragment Crystallizable region." The names are essentially interchangable. Source: Human Plasma Purity: ≥ 95% by SDS-PAGE., No reaction by IEP to antisera to human IgG-fab. Physical State: Frozen in 50 mM Tris-HCl, pH 8.0, with 200 mM NaCl and 0.05% NaN3. Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-090707-FC-1MG 1 mg 105 € 16-16-090707-FC-5MG 5 mg 430 € 16-16-090707-FC-10MG 10 mg 735 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

IgG FC, Fc stands for "Fragment Constant region" or "Fragment Crystallizable region." The names are essentially interchangable.

 

Description of Human Immunoglobulin G Fc Fragment (IgG FC)

Human Immunoglobulin G Fc Fragment (IgG FC) is a 50 kDa protein. The Fc (fragment crystallizable) region of immunoglobulin G, while not binding antigen, contains crucial biological activities and antigenic determinants. This homodimeric glycoprotein comprises CH2 and CH3 domains and mediates immune effector functions through interactions with Fc receptors, C1q, and FcRn. Fc fragments orchestrate antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and phagocytosis while controlling IgG's serum half-life via pH-dependent FcRn binding. The conserved N-linked glycosylation at Asn-297 is essential for structural stability and receptor interactions. Altered Fc glycosylation patterns correlate with autoimmune conditions including rheumatoid arthritis, where reduced galactosylation and sialylation indicate inflammatory disease states. Fc receptor polymorphisms are also associated with autoimmune disease development.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Immunoglobulin G Fc Fragment (IgG FC) at ≤ -80°C.

 

Applications

Flow Cytometry, ELISA, Antisera Production, In Vitro Diagnostics, Proteomics.

 

Citations/Publications

Zeng, J., et al., (2019), 'Rare missense variants in the human cytosolic antibody receptor preserve antiviral function', eLife, 8: pp. e48339. Available at: DOI: https://doi.org/10.7554/eLife.48339
Zhang, P., et al., (2020), 'Mechanism- and Immune Landscape-Based Ranking of Therapeutic Responsiveness of 22 Major Human Cancers to Next Generation Anti-CTLA-4 Antibodies', Cancers, 12: pp. 284. Available at: doi:10.3390/cancers12020284 
Wang, X., et al., (2022), 'CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder', Cell Metabolism, 34: pp. 1088–1103. Available at: https://doi.org/10.1016/j.cmet.2022.07.005
Liu M., et al., (2023), Soluble CTLA-4 mutants ameliorate immune-related adverse events but preserve efficacy of CTLA-4– and PD-1–targeted immunotherapy', Sci. Transl. Med., 15 (685), eabm5663. Available at: DOI: 10.1126/scitranslmed.abm5663 
Li, Y., et al., (2024), 'CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function', Front. Immunol. 15:1418539. Available at: doi: 10.3389/fimmu.2024.1418539

 

Shipped with dry ice

 

Gel Scan of Human Immunoglobulin G Fc Fragment (IgG FC)

Fig. 1: SDS-PAGE Gel

 

 

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Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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