Human Immunoglobulin G Fc Fragment (IgG FC), Immunogen Grade

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	Proteins Synonyms: IgG FC, Fc stands for "Fragment Constant region" or "Fragment Crystallizable region." The names are essentially interchangable. Source: Human Plasma Purity: 99% by SDS-PAGE; Single arc by IEP; Immunogen Grade per Western Blot Physical State: Frozen in 50 mM Tris-HCl, pH 8.0, with 200 mM NaCl and 0.05% NaN3. Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-090707-FC-IMM-1MG 1 mg 135 € 16-16-090707-FC-IMM-5MG 5 mg 525 € 16-16-090707-FC-IMM-10MG 10 mg 915 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

IgG FC, Fc stands for "Fragment Constant region" or "Fragment Crystallizable region." The names are essentially interchangable.

 

Description of Human Immunoglobulin G Fc Fragment (IgG FC), Immunogen Grade

Human Immunoglobulin G Fc Fragment (IgG FC), Immunogen Grade is a 50 kDa protein. The Fc (fragment crystallizable) region of immunoglobulin G, while not binding antigen, contains crucial biological activities and antigenic determinants. This homodimeric glycoprotein comprises CH2 and CH3 domains and mediates immune effector functions through interactions with Fc receptors, C1q, and FcRn. Fc fragments orchestrate antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and phagocytosis while controlling IgG's serum half-life via pH-dependent FcRn binding. The conserved N-linked glycosylation at Asn-297 is essential for structural stability and receptor interactions. Altered Fc glycosylation patterns correlate with autoimmune conditions including rheumatoid arthritis, where reduced galactosylation and sialylation indicate inflammatory disease states. Fc receptor polymorphisms are also associated with autoimmune disease development.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Immunoglobulin G Fc Fragment (IgG FC), Immunogen Grade at ≤ -80°C.

 

Applications

Flow Cytometry, ELISA, Antisera Production, In Vitro Diagnostics, Proteomics.

 

Shipped with dry ice

 

Gel Scan of Human Immunoglobulin G Fc Fragment (IgG FC), Immunogen Grade

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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