EN
Human Immunoglobulin G1 Fab (IgG1-M-Fab)
IgG1 Fab Fragment generated from myeloma IgG1, whole molecule
Product Overview, Sizes and Prices | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteins Synonyms: IgG1 Fab Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3. Manufacturer: |
|
|||||||||||||
Athens Research & Technology
Produktdetails
Synonyms
IgG1 Fab
Description of Human Immunoglobulin G1 Fab (IgG1-M-Fab)
Human Immunoglobulin G1 Fab (IgG1-M-Fab) is a 50 kDa protein. The IgG Fab (Fragment antigen-binding) fragment is a monovalent proteolytic product of Immunoglobulin G. Each Fab fragment retains the variable domains (VH and VL) responsible for antigen specificity while lacking the Fc-mediated effector functions, enabling targeted antigen neutralization without immune activation. This structural configuration prevents cross-linking-induced precipitation or cellular "patching/capping, " making Fab fragments ideal for precise antigen targeting in solution or on cell surfaces. Diagnostically, Fab fragments enable multiplex immunoassays by preventing Fc-mediated cross-reactivity, facilitating simultaneous detection of multiple antigens in flow cytometry and immunohistochemistry. Their monovalent nature ensures minimal background noise in assays requiring high specificity. Emerging applications include autoimmune disease management, where Fab fragments neutralize autoantibodies while circumventing complement activation. By combining targeted binding with reduced immunogenicity, IgG Fab fragments represent a versatile tool in both clinical and research settings.
Source
Human myeloma plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Immunoglobulin G1 Fab (IgG1-M-Fab) at ≤ -80°C.
Applications
Biotherapeutics, Flow Cytometry, Immunohistochemistry, Antisera Production.
Shipped with dry ice
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
To buy Human Immunoglobulin G1 Fab (IgG1-M-Fab) please click on the Shopping List Symbol right from the indicated price. This will add Human Immunoglobulin G1 Fab (IgG1-M-Fab) to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.
For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
