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Human Immunoglobulin G1 FC (IgG1-M-FC)
IgG1 Fc Fragment generated from myeloma IgG1, whole molecule
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Proteins Synonyms: IgG FC, Fc stands for "Fragment Constant region" or "Fragment Crystallizable region." The names are essentially interchangable. Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 50 mM Tris-HCl, pH 8.0, with 200 mM NaCl and 0.05% NaN3. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
IgG FC, Fc stands for "Fragment Constant region" or "Fragment Crystallizable region." The names are essentially interchangable.
Description of Human Immunoglobulin G1 FC (IgG1-M-FC)
Human Immunoglobulin G1 FC (IgG1-M-FC) is a 50 kDa protein. The Fc (fragment crystallizable) region of immunoglobulin G, while not binding antigen, contains crucial biological activities and antigenic determinants. This homodimeric glycoprotein comprises CH2 and CH3 domains and mediates immune effector functions through interactions with Fc receptors, C1q, and FcRn. Fc fragments orchestrate antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and phagocytosis while controlling IgG's serum half-life via pH-dependent FcRn binding. The conserved N-linked glycosylation at Asn-297 is essential for structural stability and receptor interactions. Altered Fc glycosylation patterns correlate with autoimmune conditions including rheumatoid arthritis, where reduced galactosylation and sialylation indicate inflammatory disease states. Fc receptor polymorphisms are also associated with autoimmune disease development.
Source
Human myeloma plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Immunoglobulin G1 FC (IgG1-M-FC) at ≤ -80°C.
Applications
Flow Cytometry, ELISA, Antisera Production, In Vitro Diagnostics, Proteomics.
Shipped with dry ice
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
