Human Immunoglobulin G1 (IgG1)

1. Home
2. Proteins
3. Human Proteins

Product Overview, Sizes and Prices
	Proteins Synonyms: IgG1-Myeloma Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3. Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-090707-1M-1MG 1 mg 175 € 16-16-090707-1M-5MG 5 mg 690 € 16-16-090707-1M-10MG 10 mg 1.200 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

IgG1-Myeloma

 

Description of Human Immunoglobulin G1 (IgG1)

Human Immunoglobulin G1 (IgG1) is a 146 kDa protein. IgG1, constituting 65% of serum IgG, is the predominant subclass critical for adaptive immunity, characterized by a flexible hinge region enabling broad antigen recognition and potent effector functions. Its Fc domain binds FcγRI/III receptors and C1q, driving antibody-dependent cellular cytotoxicity (ADCC), phagocytosis, and complement activation. In multiple myeloma, monoclonal IgG1 overproduction disrupts normal immunoglobulin synthesis, often manifesting as renal impairment or hyperviscosity syndrome. Serum IgG1 quantification aids in monitoring disease progression and treatment efficacy, with elevated ratios of IgG1/IgG (>65%) signaling clonal plasma cell expansion. Autoimmune pathologies like systemic lupus erythematosus (SLE) and Sjögren’s syndrome exhibit IgG1-predominant autoantibodies targeting nuclear antigens, exacerbating tissue inflammation via FcγR-mediated leukocyte activation. Conversely, IgG1 deficiencies (<4.9 g/L) predispose to recurrent bacterial infections due to impaired opsonization of protein antigens like tetanus toxoid. Therapeutically, myeloma-derived IgG1 serves as a standardized reagent in immunoassays and structural studies, leveraging its intact glycosylation patterns. Dysregulated IgG1 also underpins type II hypersensitivity reactions, with FcγRIII cross-linking on mast cells/basophils driving anaphylactic pathways. By balancing immune activation and homeostasis, IgG1 remains pivotal in both pathogenic mechanisms and biotherapeutic innovation.

 

Source

Human myeloma plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Immunoglobulin G1 (IgG1) at ≤ -80°C.

 

Applications

ELISA, In Vitro Diagnostic, Glycoproteomics, Biotherapeutics, Inflammation, Infection, Flow Cytometry, Autoimmune Disease, Cancer.

 

Citations/Publications

Zhang, W., et al., (2024), 'Fc–Fc interactions and immune inhibitory effects of IgG4: implications for anti-PD-1 immunotherapies', Journal for ImmunoTherapy of Cancer 12: e009034. Available at: doi:10.1136/jitc-2024-009034 
Devaux, J. J., et al., (2016), 'Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy', Neurology, 86(9): pp 800-7. Available at: doi: 10.1212/WNL.0000000000002418.
Jordakieva, G., et al., (2021), 'IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer', ONCOIMMUNOLOGY, 10(1): pp e1880687. Available at: https://doi.org/10.1080/2162402X.2021.1880687
Ermet, D., et al., (2019), 'The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus.', Front. Immunol. 10:1230. Available at: doi: 10.3389/fimmu.2019.01230 
Kammeijer, G. S. M., et al., (2016), 'Dopant Enriched Nitrogen Gas Combined with Sheathless Capillary Electrophoresis−Electrospray Ionization-Mass Spectrometry for Improved Sensitivity and Repeatability in Glycopeptide Analysis', Anal. Chem. 88: 5849−5856. Available at: DOI: 10.1021/acs.analchem.6b00479

 

Shipped with dry ice

 

Gel Scan of Human Immunoglobulin G1 (IgG1)

Fig. 1: SDS-PAGE Gel

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

To buy Human Immunoglobulin G1 (IgG1) please click on the Shopping List Symbol right from the indicated price. This will add Human Immunoglobulin G1 (IgG1) to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

 

For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.