Human Immunoglobulin G2 (IgG2)

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	Proteins Synonyms: IgG2 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3. Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-090707-2-100UG 100 µg 60 € 16-16-090707-2-1MG 1 mg 315 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

IgG2

 

Description of Human Immunoglobulin G2 (IgG2)

Human Immunoglobulin G2 (IgG2) is a 146 kDa protein. Serum IgG2 constitutes approximately 23% of total immunoglobulin G and is distinguished by a truncated 12-amino-acid hinge region with a poly-proline helix stabilized by four interchain disulfide bonds. This rigid structure limits Fab arm flexibility, reducing Fcγ receptor (FcγR) binding and complement activation compared to IgG1/IgG3. However, IgG2 excels in targeting repetitive carbohydrate antigens on encapsulated bacteria like Streptococcus pneumoniae and Haemophilus influenzae, forming high-avidity interactions critical for polysaccharide immunity. Its Fc domain binds FcγRIIA-H131 with moderate affinity, enabling phagocyte-mediated pathogen clearance in specific contexts. Deficiency in IgG2 (<2.1 g/L) impairs anti-polysaccharide responses, increasing susceptibility to recurrent sinopulmonary infections and invasive bacterial diseases. This deficiency often coexists with IgG4 or IgA deficits, complicating immune competence. Clinically, serum IgG2 quantification aids in evaluating humoral function, particularly in patients with chronic infections or hypogammaglobulinemia. Therapeutically, IgG2’s reduced Fc-mediated effector functions are exploited in oncology. Panitumumab, an IgG2 anti-EGFR monoclonal antibody, minimizes cytokine release syndrome while retaining tumor-targeting efficacy. Its inefficient FcRn-mediated transcytosis-attributed to the absence of Gly236 in the hinge-also results in lower placental transfer (~50% maternal levels), reducing fetal exposure risks. Emerging engineering strategies leverage IgG2’s structural stability for prolonged serum half-life and minimized off-target activation, enhancing therapeutic safety profiles.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Immunoglobulin G2 (IgG2) at ≤ -80°C.

 

Applications

Glycoproteomics, Inflammation, Biotherapeutics, In Vitro Diagnostic, Antimicrobial, Infection,.

 

Citations/Publications

Takayanagi, T., et al., (2016), 'Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II', Hypertension. 68: pp 949-955. Available at: DOI: 10.1161/HYPERTENSIONAHA.116.07620.
Kawai, T., et al., (2017), 'Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/β- Aminopropionitrile–Induced Abdominal Aortic Aneurysm', Hypertension. 70: pp 959-963. Available at: DOI: 10.1161/HYPERTENSIONAHA.117.09822.
Devaux, J. J., et al., (2016), 'Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy', Neurology, 86(9): pp 800-7. Available at: doi: 10.1212/WNL.0000000000002418.
Ermet, D., et al., (2019), 'The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus.', Front. Immunol. 10:1230. Available at: doi: 10.3389/fimmu.2019.01230 
Sun, X., et al., (2018), 'Identification and Characterization of Novel Fc-Binding Heptapeptides from Experiments and Simulations', Polymers, 10: pp 778. Available at: doi:10.3390/polym10070778

 

Shipped with dry ice

 

Gel Scan of Human Immunoglobulin G2 (IgG2)

Fig. 1: SDS-PAGE Gel

 

 

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Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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