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Human Immunoglobulin G4 (IgG4)
Native, IgG subclass 4 whole molecule purified from multiple donor native IgG Polyclonal
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Proteins Synonyms: IgG4 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
IgG4
Description of Human Immunoglobulin G4 (IgG4)
Human Immunoglobulin G4 (IgG4) is a 146 kDa protein. Serum IgG4 is the least abundant subclass of IgG antibodies, accounting for only 3–5% of total IgG in circulation. IgG4 possesses unique structural features, notably its ability to undergo Fab-arm exchange, resulting in bispecific antibodies with two different antigen-binding sites. Functionally, IgG4 is distinct from other IgG subclasses because it does not activate the complement system and has limited capacity for antibody-dependent cell-mediated cytotoxicity. Instead, IgG4 primarily acts as a blocking antibody, modulating immune responses and limiting inflammation. This immunomodulatory role is particularly evident in chronic antigen exposure, such as during allergen immunotherapy, where IgG4 levels rise and help suppress IgE-mediated allergic reactions. Elevated IgG4 responses are also characteristic in parasitic infections like schistosomiasis and lymphatic filariasis. Clinically, IgG4 is central to IgG4-related disease (IgG4-RD), a fibroinflammatory condition affecting multiple organs, and is implicated in certain autoimmune diseases where IgG4 autoantibodies disrupt normal tissue function. Additionally, combined IgA-IgG4 deficiency has been linked to recurrent bacterial infections due to impaired immune defense.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Immunoglobulin G4 (IgG4) at ≤ -80°C.
Applications
Inflammation, In Vitro Diagnostic, Allergy, Parasitic Infection, Autoimmune Diseases, Biotherapeutics, ELISA Standard, Flow Cytometry, Immunohistochemistry.
Citations/Publications
Li, P., et al., (2025), 'Molecular and cellular morphology of placenta unveils new mechanisms of reproductive immunology', Journal of Advanced Research. 2025. Available at: https://doi.org/10.1016/j.jare.2025.01.025
Devaux, J. J., et al., (2016), 'Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy', Neurology, 86(9): pp 800-7. Available at: doi: 10.1212/WNL.0000000000002418.
Köhler, V. K., et al., (2020), 'Filling the Antibody Pipeline in Allergy: PIPE Cloning of IgE, IgG1 and IgG4 against the Major Birch Pollen Allergen Bet v 1', Int. J. Mol. Sci. 21: pp 5693. Available at: doi:10.3390/ijms21165693
Kruljec, N., et al., (2018), 'Development and Characterization of Peptide Ligands of Immunoglobulin G Fc Region', Bioconjugate Chem. 29: pp 2763−2775. Available at: DOI: 10.1021/acs.bioconjchem.8b00395
Shah, B., et al., (2022), 'Observation of Heavy-Chain C-Terminal Amidation in Human Endogenous IgG', Journal of Pharmaceutical Sciences 111: pp 2445−2450. Available at: https://doi.org/10.1016/j.xphs.2022.06.012
Shipped with dry ice
Gel Scan of Human Immunoglobulin G4 (IgG4)
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
