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Human Immunoglobulin M (IgM)
Native, whole molecule purified from myeloma plasma
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Proteins Synonyms: IgM Myeloma Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 50 mM Tris-HCl, pH 8.0, with 200 mM NaCl and 0.05% NaN3 Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
IgM Myeloma
Description of Human Immunoglobulin M (IgM)
Human Immunoglobulin M (IgM) is a 950 kDa protein. Serum IgM is a pentameric or hexameric macro-immunoglobulin that serves as the first-line defense in humoral immunity. Constituting 1.2–4.0 mg/mL in plasma, it features 10–12 antigen-binding sites, enabling high-avidity interactions with pathogens, particularly non-protein antigens like microbial carbohydrates and lipids. As the earliest antibody produced during infection and the primary immunoglobulin in neonates, IgM activates the classical complement pathway through C1 binding, promoting opsonization and pathogen lysis. Its inability to cross the placenta makes elevated neonatal IgM a marker for intrauterine infections. IgM plays dual roles in autoimmune pathology. While natural IgM aids homeostasis by clearing cellular debris, autoreactive IgM drives diseases like cold agglutinin disease and idiopathic thrombocytopenic purpura through erythrocyte or platelet targeting4. Deficiencies manifest in Wiskott-Aldrich syndrome (linked to thrombocytopenia and recurrent infections) and Hyper IgM syndromes, characterized by impaired class-switching and susceptibility to Pneumocystis pneumonia, cryptosporidiosis, and malignancies. Clinically, IgM serves diagnostic and therapeutic purposes. It indicates recent infections through serological testing and helps identify autoimmune conditions via autoantibody detection. Intravenous immunoglobulin (IVIG) preparations containing IgM are used for immune thrombocytopenic purpura and Guillain-Barré syndrome, leveraging IgM’s immunomodulatory properties.
Source
Human myeloma plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Immunoglobulin M (IgM) at ≤ -80°C.
Applications
Complement System, In Vitro Diagnostics, Infection, Glycoproteomics, Biotherapeutics, Anaphylaxis, Rheumatoid Arthritis, Autoimmune Diseases, Wiskott-Aldrich syndrome.
Citations/Publications
Khandelwal, S., et al., (2018), 'Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway', Blood. 132(23): pp 2431-2440. Available at: https://doi.org/10.1182/blood-2018-03-834598
Ugolini, A., et al., (2020), 'IgM-Rheumatoid factor confers primary resistance to anti-PD-1 immunotherapies in NSCLC patients by reducing CD137+T-cells.', EBioMedicine 62: 103098. Available at: doi.org/10.1016/j.ebiom.2020.103098
Bettoni, S., et al., (2019), 'C4BP-IgM protein as a therapeutic approach to treat Neisseria gonorrhoeae infections', JCI Insight. 4(23): e131886. Available at: https://doi.org/10.1172/jci.insight.131886
Shipped with dry ice
Gel Scan of Human Immunoglobulin M (IgM)
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
