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Human Immunoglobulin M (IgM), Fc5u Fragment
Native IgM Fragment. Processed from Human IgM from pooled donor source material. IgM Fc5u is a pentameric fragment resulting from the proteolytic cleavage of whole molecule human IgM
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Proteins Synonyms: IgM Fc5μ, IgM FC5mu, Fc stands for "Fragment Constant region" or "Fragment Crystallizable region." The names are essentially interchangable. Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. No reaction by IEP to antisera to kappa or lambda Physical State: Frozen in PBS, pH 7.4 Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
IgM Fc5μ, IgM FC5mu, Fc stands for "Fragment Constant region" or "Fragment Crystallizable region." The names are essentially interchangable.
Description of Human Immunoglobulin M (IgM), Fc5u Fragment
Human Immunoglobulin M (IgM), Fc5u Fragment is a 342 kDa protein. The Immunoglobulin M (IgM) Fc5µ fragment, comprising the constant region (Cµ2-Cµ4 domains) of the µ heavy chain, mediates critical immune functions despite lacking antigen-binding capacity. This fragment drives complement fixation via C1q binding, with studies showing its pentameric form in Waldenström macroglobulinemia exhibits 19-fold higher complement activation than intact IgM. Structurally, the Fc5µ's conserved N-glycosylation at Asn-297 stabilizes its conformation and enables interactions with Fc receptors (FcµR) on B cells, T cells, and NK cells, modulating immune responses like phagocytosis and antibody-dependent cytotoxicity. While IgM typically lacks placental transfer due to its size, Fc5µ's interaction with FcRn-a receptor critical for IgG transcytosis-hints at nuanced roles in maternal-fetal immunity, though this requires further elucidation.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Immunoglobulin M (IgM), Fc5u Fragment at ≤ -80°C.
Applications
Structural Studies, Antisera Production.
Citations/Publications
Scarrone, M., et al., (2021), 'Development of anti-human IgM nanobodies as universal reagents for general immunodiagnostics', New BIOTECHNOLOGY 64: pp 9–16. Available at: https://doi.org/10.1016/j.nbt.2021.05.002
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Gel Scan of Human Immunoglobulin M (IgM), Fc5u Fragment
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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