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Human Inter Alpha Inhibitor Proteins
Native, whole molecule mixture of Inter Alpha Trypsin Inhibitor (IaI) and Pre Alpha Inhibitor (PaI)
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Proteins Synonyms: IaIP, IαIP Biological Activity: Shows inhibitory activity when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate. Source: Human Plasma Purity: ≥ 90% by SDS-PAGE Physical State: Frozen in 1 x PBS Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
IaIP, IαIP
Description of Human Inter Alpha Inhibitor Proteins
Inter Alpha Inhibitor Proteins (IaIp) are a family of serine protease inhibitors present in human plasma, including Inter Alpha Trypsin Inhibitor (IaI, 225 kDa) and Pre Alpha Inhibitor (Pal, 125 kDa), with a combined concentration of about 50 mg/100 mL. Their inhibitory function is primarily mediated by bikunin, a conserved light chain with Kunitz-type domains that neutralizes proteases and modulates inflammation. IaIp play a critical role in the regulation of extracellular matrix stability by interacting with hyaluronic acid, which is essential for tissue integrity and repair. During acute inflammation, IaI acts as a negative acute-phase protein while Pal serves as a positive acute-phase protein, reflecting their dynamic involvement in immune responses. Clinically, IaIp have emerged as biomarkers and potential therapies for conditions such as sepsis, metastatic disease, stroke, and complement system disorders due to their ability to neutralize proinflammatory cytokines, inhibit complement activation, and protect against histone-induced cytotoxicity and tissue damage2. Additionally, specific IaIp components are being investigated as biomarkers for autoimmune diseases like myasthenia gravis.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Biological Activity
Shows inhibitory activity when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.
Storage
For long term, store Human Inter Alpha Inhibitor Proteins at ≤ -80°C.
Applications
Inhibitor Assay, Inflammation, In Vitro Diagnostic, Sepsis, Stroke, Complement System, Autoimmune Diseases.
Citations/Publications
Tellier, L. E., et al., (2018), 'Intra-articular TSG-6 delivery from heparin-based microparticles reduces cartilage damage in a rat model of osteoarthritis', Biomater. Sci., 6: 1159–1167. Available at DOI: 10.1039/c8bm00010g
Fasanello, D. C., et al., (2021), 'Hyaluronic acid synthesis, degradation, and crosslinking in equine osteoarthritis: TNF-α-TSG-6-mediated HC-HA formation.', Arthritis Research & Therapy 23: pp 218. Available at: https://doi.org/10.1186/s13075-021-02588-7
Sato, T., et al., (2020), 'A Novel Type of Stem Cells Double-Positive for SSEA-3 and CD45 in Human Peripheral Blood', Cell Transplantation 29: pp 1–16. Available at: DOI: 10.1177/0963689720923574
Shipped with dry ice
Gel Scan of Human Inter Alpha Inhibitor Proteins
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
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