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Human Kallikrein
Native whole molecule, biologically active
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Proteins Synonyms: KK, KLKB1, Kininogenase, Kininogenin, Fletcher factor, KLK3 Biological Activity: 15 units per mg Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 20 mM Tris-HCl, pH 7.8, with 100 mM NaCl Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
KK, KLKB1, Kininogenase, Kininogenin, Fletcher factor, KLK3
Description of Human Kallikrein
Human Kallikrein is a 86000-88000 Da protein. Kallikrein is a family of secreted serine proteases with diverse physiological roles, most notably in the generation of bradykinin, a potent vasodilator involved in regulating blood pressure, inflammation, and pain. In plasma, kallikrein exists as an inactive precursor called prekallikrein, which is synthesized in the liver and activated by factor XII during the intrinsic coagulation pathway. Upon activation, kallikrein cleaves kininogen to release bradykinin, thereby increasing vascular permeability and contributing to inflammatory responses. Structurally, kallikreins share a conserved catalytic triad essential for their proteolytic activity and are stabilized by multiple disulfide bridges. Clinically, dysregulation of kallikrein activity is implicated in hereditary angioedema (HAE), a rare genetic disorder characterized by episodes of severe swelling due to excessive bradykinin production. Kallikrein inhibitors are used therapeutically to manage HAE by blocking bradykinin release and preventing angioedema attacks. Additionally, kallikreins play roles in blood clotting, skin desquamation, and are being studied for their involvement in cancer, kidney function, and other inflammatory diseases.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Biological Activity
15 units per mg. One unit is defined as the amount of enzyme that hydrolyzes one umole of D-Pro-Phe-Arg-pNA per minute at 25°C, pH 7.8.
Storage
For long term, store Human Kallikrein at ≤-20°C.
Applications
Inhibitor Assay, Rheumatoid Arthritis, Complement System, Diabetes, Hereditary Angioedema , Coagulation.
Citations/Publications
Irmscher, S., et al., (2017), 'Kallikrein Cleaves C3 and Activates Complement', J Innate Immun 10: pp 94–105. Available at: DOI: 10.1159/000484257
Tivawala, R., et al., (2018), 'The Rheumatoid Arthritis-Associated Citrullinome', Cell Chemical Biology 25, pp 691–704. Available at: https://doi.org/10.1016/j.chembiol.2018.03.002
NCBI: https://www.ncbi.nlm.nih.gov/protein/P03952/
Shipped with ice packs
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
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