Human Kininogen, High Molecular Weight (HMW)

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	Proteins Synonyms: HMWK, Fitzgerald factor, Alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 10 mM Na acetate, pH 5.5, with 250 mM NaCl Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-110914-H-100UG 100 µg 200 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

HMWK, Fitzgerald factor, Alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor

 

Description of Human Kininogen, High Molecular Weight (HMW)

Human Kininogen, High Molecular Weight (HMW) is a 120 kDa protein. High Molecular Weight Kininogen (HMWK) is a multifunctional plasma protein primarily synthesized by hepatocytes. As the precursor to bradykinin, HMWK plays a central role in the kallikrein-kinin system, where it is cleaved by plasma kallikrein to release bradykinin, a peptide that mediates vasodilation, increased vascular permeability, and pain signaling. Beyond its role as a bradykinin precursor, HMWK functions as a critical cofactor in the intrinsic pathway of blood coagulation, facilitating the activation of factors XI, XII, and prekallikrein. Additionally, HMWK acts as a major extracellular cysteine proteinase inhibitor, helping to regulate proteaseTyp activity and protect tissues from excessive proteolysis. Dysregulation of HMWK has been implicated in various pathological conditions, including hereditary angioedema, where bradykinin overproduction leads to recurrent swelling episodes. Furthermore, altered kininogen activity is associated with cancer progression, muscular dystrophy, and joint diseases, making HMWK a potential therapeutic target and biomarker in these disorders.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Kininogen, High Molecular Weight (HMW) at ≤ -80°C.

 

Applications

Angiodema, Diabetes, Coagulation, Cancer, Muscular Dystrophy, Joint Disease, In Vitro Diagnostic.

 

Citations/Publications

NCBI: https://www.ncbi.nlm.nih.gov/protein/P01042/

 

Shipped with dry ice

 

Gel Scan of Human Kininogen, High Molecular Weight (HMW)

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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