Human Kininogen, Low Molecular Weight (LMW)

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	Proteins Synonyms: LMWK, Fitzgerald factor, Alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 10 mM Na acetate, pH 5.5, with 200 mM NaCl. Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-110914-L-100UG 100 µg 165 € 16-16-110914-L-1MG 1 mg 945 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

LMWK, Fitzgerald factor, Alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor

 

Description of Human Kininogen, Low Molecular Weight (LMW)

Human Kininogen, Low Molecular Weight (LMW) is a 65 kDa protein. Low Molecular Weight Kininogen (LMWK) is a plasma protein produced through alternative splicing of the KNG1 gene and consists of 427 amino acids. Unlike its high molecular weight counterpart, LMWK is not directly involved in blood coagulation but plays a key role in blood pressure regulation and vascular homeostasis. It serves as an endogenous substrate for tissue kallikrein, which cleaves LMWK to release kallidin-a vasoactive peptide that can be further converted to bradykinin-both of which induce vasodilation and increase vascular permeability, thereby influencing blood pressure and inflammatory responses. Additionally, LMWK acts as a major extracellular cysteine protease inhibitor, helping regulate protease activity in tissues and contributing to protection against excessive proteolysis. Altered levels or dysfunction of kininogens have been associated with conditions such as inflammation, diabetes, myocardial infarction, and certain cancers3. LMWK and its cleavage products are also being explored as potential biomarkers and therapeutic targets in cardiovascular and inflammatory diseases.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Kininogen, Low Molecular Weight (LMW) at ≤-20°C.

 

Applications

Hypertension, Inflammation, In Vitro Diagnostic, Cancer, Diabetes, In Vitro Diagnostics.

 

Citations/Publications

NCBI: https://www.ncbi.nlm.nih.gov/protein/P01042/

 

Shipped with ice packs

 

Gel Scan of Human Kininogen, Low Molecular Weight (LMW)

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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