Human Lactoferrin, Neutrophil

1. Home
2. Proteins
3. Human Proteins

Product Overview, Sizes and Prices
	Proteins Synonyms: LF, LFT, Lactotransferrin, Growth-inhibiting protein 12 Talalactoferrin Source: Human Neutrophils Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 100 mM Tris-HCl, pH 8.0, with 300 mM NaCl Manufacturer:  Athens Research & Technology	Article No. Size Price   16-14-120103-50UG 50 µg 165 € 16-14-120103-100UG 100 µg 300 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

LF, LFT, Lactotransferrin, Growth-inhibiting protein 12 Talalactoferrin

 

Description of Human Lactoferrin, Neutrophil

Human Lactoferrin, Neutrophil is a 78 kDa protein. Neutrophil lactoferrin is a multifunctional glycoprotein stored in the secondary granules of polymorphonuclear neutrophils and released during immune responses. In addition to its presence in exocrine secretions such as saliva, tears, and milk, neutrophil-derived lactoferrin plays a pivotal role in the body’s innate defense mechanisms. Upon release, it binds free iron with high affinity, limiting iron availability to invading bacteria and thereby exerting potent bacteriostatic and bactericidal effects. This iron-sequestration not only inhibits microbial growth but also helps modulate inflammatory responses at sites of infection. Furthermore, neutrophil lactoferrin regulates intestinal iron absorption, contributing to iron homeostasis and preventing iron overload or deficiency. Clinically, altered levels of neutrophil lactoferrin have been associated with inflammatory diseases, infections, and certain autoimmune conditions. Its antimicrobial and immunomodulatory properties make it a promising candidate for therapeutic applications in treating infections, inflammatory disorders, and supporting immune health.

 

Source

Neutrophils shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

 

Storage

For long term, store Human Lactoferrin, Neutrophil at ≤ -80°C.

 

Applications

Iron Transport, Antimicrobial, Inflammation, Immunology, Infection.

 

Citations/Publications

Creager, H. M., et al., (2018), 'Infection and Replication of Influenza Virus at the Ocular Surface', J Virol 92: pp e02192-17. Available at: https://doi.org/10.1128/JVI.02192-17
Choi, S. R., et al., (2021), 'Nanoparticulate β‐Cyclodextrin with Gallium Tetraphenylporphyrin Demonstrates in Vitro and in Vivo Antimicrobial Efficacy against Mycobacteroides abscessus and Mycobacterium avium', ACS Infect. Dis. 7: pp 2299−2309. Available at: https://doi.org/10.1021/acsinfecdis.0c00896
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02788

 

Shipped with dry ice

 

Gel Scan of Human Lactoferrin, Neutrophil

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

To buy Human Lactoferrin, Neutrophil please click on the Shopping List Symbol right from the indicated price. This will add Human Lactoferrin, Neutrophil to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

 

For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.