Human Lipoprotein a, [Lp(a)]

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	Proteins Synonyms: Lp(a) Source: Human Plasma Purity: Essentially free of other plasma lipoproteins as determined by electrophoresis using a SPIFE Vis Cholesterol gel kit for lipids and Coomassie Blue for proteins. ≥ 95% of total lipoprotein content by electrophoresis. SDS-PAGE shows minor ApoA1 contaminant Physical State: Liquid in 1X PBS with 0.05% NaN3 Manufacturer:  Athens Research & Technology	Article No. Size Price   12-16-121601-100UG 100 µg 205 € 12-16-121601-1MG 1 mg 1.025 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

Lp(a)

 

Description of Human Lipoprotein a, [Lp(a)]

Human Lipoprotein a, [Lp(a)] is a 280000-700000 Da protein. Lipoprotein(a), or Lp(a), is a specialized lipoprotein particle found in plasma at concentrations typically ranging from 20 to 760 mg/L, with levels largely determined by genetic factors1. Structurally, Lp(a) consists of an LDL-like core bound to apolipoprotein(a), which imparts unique proatherogenic and prothrombotic properties. Elevated Lp(a) is an independent and causal risk factor for atherosclerotic cardiovascular diseases, including coronary artery disease, heart attack, stroke, aortic stenosis, and peripheral artery disease. Lp(a) promotes vascular inflammation and plaque formation by accumulating in vessel walls and carrying oxidized phospholipids, which trigger inflammatory responses and calcification67. It also interferes with fibrinolysis, increasing the risk of thrombosis. Currently, no FDA-approved therapies specifically target Lp(a) reduction, but its measurement can help identify individuals at high cardiovascular risk who may benefit from intensified preventive strategies. Research into targeted Lp(a)-lowering treatments is ongoing, offering hope for future clinical applications.

 

Source

Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

 

Storage

For long term, store Human Lipoprotein a, [Lp(a)] at +2 to 8°C.

 

Applications

In Vitro Diagnostics, Cardiovascular Disease, Inflammation.

 

Citations/Publications

Diaz, N., et al., (2024), 'Discovery of potent small-molecule inhibitors of lipoprotein(a) formation', Nature 629: pp 945–950. Available at: https://doi.org/10.1038/s41586-024-07387-z
Yu, B., et al., (2018), 'Pathological significance of lipoprotein(a) in aortic valve stenosis', Atherosclerosis 272: pp 168-174. Available at: https://doi.org/10.1016/j.atherosclerosis.2018.03.025

 

Shipped with ice packs

 

Gel Scan of Human Lipoprotein a, [Lp(a)]

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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