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Human Lipoprotein, Low Density, Oxidized (LDL-OX)
Whole molecule that has been oxidized post purification
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Proteins Synonyms: LDL-ox, oxLDL Source: Human Plasma Purity: ≥ 95% by electrophoresis Physical State: Liquid in PBS +0.2mM EDTA, pH 7.4 Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
LDL-ox, oxLDL
Description of Human Lipoprotein, Low Density, Oxidized (LDL-OX)
Human Lipoprotein, Low Density, Oxidized (LDL-OX) is a 2300 kDa protein. Oxidized low-density lipoprotein (Ox-LDL) is a modified form of LDL in which both the lipid and protein components, particularly apolipoprotein B-100, undergo oxidative changes. These modifications include the formation of aldehydes, cross-linking of amino acids, and the generation of new antigenic epitopes, making Ox-LDL structurally and functionally distinct from native LDL. Functionally, Ox-LDL is recognized and taken up by macrophage scavenger receptors, leading to foam cell formation-a key step in atherogenesis. Ox-LDL also acts as a cytotoxin, injuring endothelial cells, increasing endothelial permeability, and promoting inflammatory responses, which further contribute to vascular dysfunction and lesion development. Clinically, elevated levels of Ox-LDL are strongly associated with atherosclerosis, metabolic syndrome, type 2 diabetes, and coronary heart disease. Ox-LDL is implicated in the progression of these diseases due to its pro-inflammatory and cytotoxic effects on vascular cells. In research and diagnostics, Ox-LDL is used to study cellular responses to oxidative stress, to assess cardiovascular risk, and as a probe in assays such as ELISA, Western blot, and fluorescence microscopy to track its uptake and effects in biological systems.
Source
Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Storage
For long term, store Human Lipoprotein, Low Density, Oxidized (LDL-OX) at +2 to 8°C.
Applications
Cell Culture Media, In Vitro Diagnostics, Assay Development, Cardiovascular Disease, Diabetes, Inflammation, Oxidative Stress.
Citations/Publications
Dai, X., et al., (2017), 'Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia', Circ Res. 120: pp e7-e23. Available at: DOI: 10.1161/CIRCRESAHA.117.310619
Pham, L. M., et al., (2021), 'Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis', Biomaterials 269: pp 120677. Available at: https://doi.org/10.1016/j.biomaterials.2021.120677
Chen, J., et al., (2024), ' Atherosclerotic three-layer nanomatrix vascular sheets for high-throughputtherapeutic evaluation', Biomaterials 305: pp 122450. Available at: https://doi.org/10.1016/j.biomaterials.2023.122450
Zhu, Y., et al., ( 2025), 'Oxidative stress promotes lipid-laden macrophage formation via CYP1B1', Redox Biology 79: pp 103481. Available at: https://doi.org/10.1016/j.redox.2024.103481
Tan, L. X., et al., (2016), 'Protective responses to sublytic complement in the retinal pigment epithelium', PNAS August 2, 113(31): pp 8789-8794. Available at: https://doi.org/10.1073/pnas.1523061113
Shipped with ice packs
Gel Scan of Human Lipoprotein, Low Density, Oxidized (LDL-OX)
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
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