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Human Lipoproteins, High Density (HDL)
Native whole molecule
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Proteins Synonyms: HDL Source: Human Plasma Purity: ≥ 95% by electrophoresis Physical State: Liquid in 150 mM NaCl, pH 7.4, and 0.01% EDTA Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
HDL
Description of Human Lipoproteins, High Density (HDL)
Human Lipoproteins, High Density (HDL) is a 175000-360000 Da protein. High-density lipoprotein (HDL) is a crucial plasma lipoprotein, present at concentrations of 1.0–2.0 g/L in healthy fasting individuals. HDL plays a central role in reverse cholesterol transport, a process in which it collects excess cholesterol from peripheral tissues and transports it back to the liver for excretion or recycling. This function helps maintain cellular cholesterol balance and prevents the buildup of cholesterol in blood vessel walls. HDL also facilitates cholesterol esterification, converting free cholesterol into cholesteryl esters for safe transport in the bloodstream. Beyond lipid transport, HDL exhibits anti-inflammatory, antioxidant, and antithrombotic properties, contributing to vascular health. Clinically, higher HDL levels are strongly associated with a reduced risk of coronary heart disease and atherosclerosis, making it a key biomarker in cardiovascular risk assessment. Therapeutic strategies aimed at raising HDL or enhancing its function are under investigation, with the goal of reducing cardiovascular events and improving long-term heart health.
Source
Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Storage
For long term, store Human Lipoproteins, High Density (HDL) at +2 to 8°C.
Applications
Cell Culture Media, In Vitro Diagnostics, Assay Development, Cardiovascular Disease.
Citations/Publications
Liu, C. C., et al., (2022), 'Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function', Nature Neuroscience. 25: pp 1020–1033. Available at: https://doi.org/10.1038/s41593-022-01127-0
Zhong, C. C., et al., (2018), 'Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species', Acta Pharmacologica Sinica 39: pp 1048–1063. Available at: doi: 10.1038/aps.2017.199;
Zhang, C., et al., (2019), 'von Willebrand factor self-association is regulated by the shear-dependent unfolding of the A2 domain', Blood Adv 3(7): pp 957–968. Available at: https://doi.org/10.1182/bloodadvances.2018030122
Tarlton, J. M. R., et al., (2021), 'Protection against Glucolipotoxicity by High Density Lipoprotein in Human PANC-1 Hybrid 1.1B4 Pancreatic Beta Cells: The Role of microRNA', Biology 10: pp 218. Available at: https://doi.org/10.3390/biology10030218
Bassila, C., et al., (2024), 'Ligand-dependent interactions between SR-B1 and S1PR1 in macrophages and atherosclerotic plaques', J. Lipid Res. 65(5): pp 100541. Available at: https://doi.org/10.1016/j.jlr.2024.100541
Shipped with ice packs
Gel Scan of Human Lipoproteins, High Density (HDL)
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
