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Human Lipoproteins, Low Density (LDL)
Native whole molecule
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Proteins Synonyms: LDL, β-Lipoprotein, LDL, Low density lipoprotein Source: Human Plasma Purity: ≥ 95% by electrophoresis Physical State: Liquid in 150 mM NaCl, pH 7.4, and 0.01% EDTA Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
LDL, β-Lipoprotein, LDL, Low density lipoprotein
Description of Human Lipoproteins, Low Density (LDL)
Human Lipoproteins, Low Density (LDL) is a 2300 kDa protein. Low-density lipoprotein (LDL) is a major plasma lipoprotein, with normal fasting concentrations ranging from 2.0 to 3.5 g/L, and accounts for about 50% of the total lipoprotein mass in the bloodstream. LDL’s primary role is to transport cholesterol and cholesteryl esters from the liver to peripheral tissues, where cholesterol is essential for membrane structure and steroid hormone synthesis. The protein component, apolipoprotein B-100, enables LDL to bind to LDL receptors on cell surfaces, facilitating cholesterol uptake via receptor-mediated endocytosis. Elevated LDL levels are a well-established risk factor for atherosclerosis and coronary heart disease, as excess LDL cholesterol can accumulate in arterial walls, triggering inflammation and plaque formation. LDL is also implicated in other conditions such as stroke and peripheral artery disease. Clinically, LDL measurement is central to cardiovascular risk assessment and guides therapeutic interventions. In research, LDL is used to study lipid metabolism, receptor interactions, and the development of lipid-lowering drugs.
Source
Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Storage
For long term, store Human Lipoproteins, Low Density (LDL) at +2 to 8°C.
Applications
Cell Culture Media, In Vitro Diagnostics, Assay Development, Cardiovascular Disease.
Citations/Publications
Liu, C. C., et al., (2022), 'Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function', Nature Neuroscience. 25: pp 1020–1033. Available at: https://doi.org/10.1038/s41593-022-01127-0
Lösslein, A. K., et al., (2021), 'Monocyte progenitors give rise to multinucleated giant cells', NATURE COMMUNICATIONS. 12: pp 2027. Available at: https://doi.org/10.1038/s41467-021-22103-5
Ma, G., et al., (2022), 'Label-Free Single-Molecule Pulldown for the Detection of Released Cellular Protein Complexes', ACS Central Science 8(9): pp 1272-1281. Available at: https://doi.org/10.1021/acscentsci.2c00602
Tan, L. X., et al., (2016), 'Protective responses to sublytic complement in the retinal pigment epithelium', PNAS 113(31): pp 8789-8794. Available at: https://doi.org/10.1073/pnas.1523061113
Zhang, P., et al., (2021), 'Quantification of Single-Molecule Protein Binding Kinetics in Complex Media with Prism-Coupled Plasmonic Scattering Imaging', ACS Sens. 6: pp 1357−1366. Available at: https://dx.doi.org/10.1021/acssensors.0c02729
Shipped with ice packs
Gel Scan of Human Lipoproteins, Low Density (LDL)
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
