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Human Lipoproteins, Low Density, Tissue Culture Grade (LDL-TC)
Native whole molecule, tissue culture grade
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Proteins Synonyms: LDL-TC, LDL-LEL, β-Lipoprotein, LDL, Low density lipoprotein Source: Human Plasma Purity: Single arc by IEP against antisera to whole human serum. Essentially free of other plasma lipoproteins as determined by electrophoresis using a SPIFE Vis Cholesterol gel kit for lipids and Coomassie Blue for proteins. ≥ 95% of the total lipoprotein content by electrophoresis. Endotoxin Level: ≤ 10 EU/mg measured by LAL Endoclot Test Physical State: Liquid in 150 mM NaCl, pH 7.4, and 0.01% EDTA Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
LDL-TC, LDL-LEL, β-Lipoprotein, LDL, Low density lipoprotein
Description of Human Lipoproteins, Low Density, Tissue Culture Grade (LDL-TC)
Human Lipoproteins, Low Density, Tissue Culture Grade (LDL-TC) is a 2300 kDa protein. Low-density lipoprotein (LDL) is a major plasma lipoprotein, with normal fasting concentrations ranging from 2.0 to 3.5 g/L, and accounts for about 50% of the total lipoprotein mass in the bloodstream. LDL’s primary role is to transport cholesterol and cholesteryl esters from the liver to peripheral tissues, where cholesterol is essential for membrane structure and steroid hormone synthesis. The protein component, apolipoprotein B-100, enables LDL to bind to LDL receptors on cell surfaces, facilitating cholesterol uptake via receptor-mediated endocytosis. Elevated LDL levels are a well-established risk factor for atherosclerosis and coronary heart disease, as excess LDL cholesterol can accumulate in arterial walls, triggering inflammation and plaque formation. LDL is also implicated in other conditions such as stroke and peripheral artery disease. Clinically, LDL measurement is central to cardiovascular risk assessment and guides therapeutic interventions. In research, LDL is used to study lipid metabolism, receptor interactions, and the development of lipid-lowering drugs.
Source
Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Storage
For long term, store Human Lipoproteins, Low Density, Tissue Culture Grade (LDL-TC) at +2 to 8°C.
Applications
Cell Culture Media, In Vitro Diagnostics, Assay Development, Cardiovascular Disease.
Shipped with ice packs
Gel Scan of Human Lipoproteins, Low Density, Tissue Culture Grade (LDL-TC)
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
