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Human Lysozyme
Native, whole molecule, biologically active
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Proteins Synonyms: LYZ, Muramidase, N-acetylmuramide glycanhydrolase, 1, 4-beta-N-acetylmuramidase C, LZM Biological Activity: > 30, 000 sugar units per mg Source: Human Neutrophils Purity: ≥ 95% by SDS-PAGE. Physical State: Lyophilized from 50 mM Na acetate, pH 6.0 with 100 mM NaCl Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
LYZ, Muramidase, N-acetylmuramide glycanhydrolase, 1, 4-beta-N-acetylmuramidase C, LZM
Description of Human Lysozyme
Human Lysozyme is a 14.7 kDa protein. Lysozyme is a compact, globular protein found abundantly in the specific granules of human polymorphonuclear leukocytes, as well as in various secretions such as tears, saliva, and egg white. Its primary function is to provide innate immune defense by hydrolyzing the β-1, 4 glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in the peptidoglycan layer of bacterial cell walls, particularly targeting Gram-positive bacteria. Lysozyme’s active site, located in a deep groove on its surface, binds to bacterial polysaccharide chains, facilitating their cleavage and leading to bacterial lysis and death. Beyond its antibacterial role, lysozyme exhibits antifungal and antiviral activities and modulates immune responses by influencing cytokine production and inflammation. Clinically, lysozyme has been explored for therapeutic applications in infections, inflammation, cancer, and wound healing, and is used as a natural preservative in food and pharmaceuticals due to its antimicrobial properties. Its broad functionality and safety profile make lysozyme valuable in biotechnology, medicine, and industry.
Source
Neutrophils shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Biological Activity
> 30, 000 sugar units per mg. One unit is defined as the amount of enzyme that digests powdered cells of Micrococcus lysodeikticus, causing a decrease in absorbance of 0.001 per minute at 37°C, pH 7.0.
Storage
For long term, store Human Lysozyme at ≤ -20°C.
Applications
In Vitro Diagnostic, Aptamers, Infection, Inflammation.
Citations/Publications
Epaud, R., et al., (2019), 'Bacterial killing is enhanced by exogenous administration of lysozyme in the lungs', Respir. Med and Res 76: pp 22–27. Available at: https://doi.org/10.1016/j.resmer.2019.07.005
NCBI: https://www.ncbi.nlm.nih.gov/protein/P61626/
Shipped with ice packs
Gel Scan of Human Lysozyme
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
