Human MDG-1 recombinant Protein
Microvascular endothelial differentiation gene 1 protein, DnaJ homolog subfamily B member 9, ERdj4.
Description of Human MDG-1
Angiogenesis research has focused on receptors and ligands mediating endothelial cell proliferation and migration. Little is known about the molecular mechanisms that are involved in converting endothelial cells from a proliferative to a differentiated state. Microvascular differentiation gene 1 (Mdg1) has been isolated from differentiating microvascular endothelial cells that had been cultured in collagen type I gels (3D culture). In adult human tissue Mdg1 is expressed in endothelial and epithelial cells. Sequence analysis of the full-length cDNA revealed that the N-terminal region of the putative Mdg1-protein exhibits a high sequence similarity to the J-domain of Hsp40 chaperones. It was shown that this region functions as a bona fide J-domain as it can replace the J-domain of Escherichia coli DnaJ-protein. Mdg1 is also upregulated in primary endothelial and mesangial cells when subjected to various stress stimuli. GFP–Mdg1 fusion constructs showed the Mdg1-protein to be localized within the cytoplasm under control conditions. Stress induces the translocation of Mdg1 into the nucleus, where it accumulates in nucleoli. Costaining with Hdj1, Hdj2, Hsp70, and Hsc70 revealed that Mdg1 colocalizes with Hsp70 and Hdj1 in control and stressed HeLa cells. These data suggest that Mdg1 is involved in the control of cell cycle arrest taking place during terminal cell differentiation and under stress conditions.
Amino Acid Sequence
MKHHHHHHSA GLEVLFQGPM ASKSYYDTLG VPKSASERQI KKAFHKLAMK YHPDKNKSPD AEAKFREIAE AYETLSDANR RKEYDTLGHS AFTSGKGQRG SGSSFEQSFN FNFDDLFKDF GFFGQNQNTG SKKRFENHFQ TRQDGGSSRQ RHHFQEFSFG GGLFDDMFED MEKMFSFSGF DSTNQHTVQT ENRFHGSSKH CRTVTQRRGN MVTTYTDCSG Q
Shipped at room temperature
To buy Human MDG-1 please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.
All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Paying by bank transfer
We ship with UPS
Free shipping for orders above 500 € within Germany