Human/Murine FGF-8b recombinant Protein

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Phone: +49 (0) 40 . 43 20 84 48 0

E-Mail: info@active-bioscience.de

 

Product Overview, Sizes and Prices

 

Protein

Synonyms: Fibroblast Growth Factor-8, AIGF, HBGF-8, KAL-6

Source: E. coli

Biological activity: ≥ 1.1 x 106units/mg

Purity: ≥ 95 % (SDS-PAGE, HPLC)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1376.950.005 5 g 60 €
1376.950.025 25 g 159 €
1376.950.100 100 g 475 €
1376.950.199 1 mg 2.390 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

Fibroblast Growth Factor-8, AIGF, HBGF-8, KAL-6

 

Description of Human/Murine FGF-8b

Recombinant Human/ Murine FGF-8b is a 194 amino acid protein, with a molecular mass of 22,5 kDa. Fibroblast Growth Factor-8B (FGF-8b) is a secreted, heparin-binding growth factor belonging to the fibroblast growth factor (FGF) family. FGF family members possess extensive mitogenic and cell survival functions, and are involved in various biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. There are 4 known alternate spliced forms of FGF-8: FGF-8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF-8A and B are identical, unlike human and mouse FGF-8E and F, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. FGF8 over expression increases tumor growth and angiogensis. The adult expression of FGF-8 gene is restricted to testes and ovaries. FGF8 functions as an embryonic epithelial factor.

 

Biological Activity

The ED50 of ≤ 0,9 ng/ml was determined by the dose-dependent stimulation of proliferation of NR6-R 3T3 cells. It corresponds to a specific activity of ≥ 1.1 x 106 units/mg.

 

Reconstitution

We recommend a quick spin followed by reconstitution in sterile water to a concentration of at least 100 g/ml. Do not vortex. This solution can be stored at 2-8C for up to 1 week or in working aliquots at -20C to -80C. Working aliquots should be at the highest practical concentration. For long term storage we recommend to add at least 0.1% HSA (order number: 2835.955.xyz or 2835.958.xyz) or BSA.

 

Stability

The lyophilized protein is stable at room temperature for up to 1 month and at least until the lot specific expiry date if kept below -18C. Reconstituted FGF-8b should be stored in working aliquots at -20C to -80C if possible with carrier protein. Please avoid repeated freeze thaw cycles.

 

Amino Acid Sequence

MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

 

To buy Human/Murine FGF-8b please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button Shopping List & Order Form to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

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Errors, changes and availability excepted.

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500  within Germany

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