Human/Murine FGF-8b recombinant Protein
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Fibroblast Growth Factor-8, AIGF, HBGF-8, KAL-6
Description of Human/Murine FGF-8b
Recombinant Human/ Murine FGF-8b is a 194 amino acid protein, with a molecular mass of 22,5 kDa. Fibroblast Growth Factor-8B (FGF-8b) is a secreted, heparin-binding growth factor belonging to the fibroblast growth factor (FGF) family. FGF family members possess extensive mitogenic and cell survival functions, and are involved in various biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. There are 4 known alternate spliced forms of FGF-8: FGF-8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF-8A and B are identical, unlike human and mouse FGF-8E and F, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. FGF8 over expression increases tumor growth and angiogensis. The adult expression of FGF-8 gene is restricted to testes and ovaries. FGF8 functions as an embryonic epithelial factor.
The ED50 of ≤ 0,9 ng/ml was determined by the dose-dependent stimulation of proliferation of NR6-R 3T3 cells. It corresponds to a specific activity of ≥ 1.1 x 106 units/mg.
We recommend a quick spin followed by reconstitution in sterile water to a concentration of at least 100 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week or in working aliquots at -20°C to -80°C. Working aliquots should be at the highest practical concentration. For long term storage we recommend to add at least 0.1% HSA (order number: 2835.955.xyz or 2835.958.xyz) or BSA.
The lyophilized protein is stable at room temperature for up to 1 month and at least until the lot specific expiry date if kept below -18°C. Reconstituted FGF-8b should be stored in working aliquots at -20°C to -80°C if possible with carrier protein. Please avoid repeated freeze thaw cycles.
Amino Acid Sequence
MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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