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Human Plasminogen
Native, whole molecule, biologically active
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Proteins Synonyms: Profibrinolysin, PLG, PM, Plasma Trypsinogen Biological Activity: >= 120 units per mg protein Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. Physical State: Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
Profibrinolysin, PLG, PM, Plasma Trypsinogen
Description of Human Plasminogen
Human Plasminogen is a 90000 to 92000 Da protein. Plasminogen is a glycoprotein present in human plasma at approximately 12 mg per 100 ml and serves as the precursor to plasmin, a key serine protease in fibrinolysis. Synthesized in the liver, plasminogen circulates in a closed, activation-resistant conformation until it binds to fibrin or cell surfaces, where it is converted to active plasmin by tissue plasminogen activator (tPA) or urokinase. Plasminogen contains multiple kringle domains that facilitate its binding to lysine residues on fibrin and cell surfaces, enhancing its localization and activation. Functionally, plasminogen is essential not only for the dissolution of blood clots but also for tissue remodeling, inflammation, cell migration, and the removal of misfolded or aggregated proteins. Deficiency in plasminogen, particularly type I (hypoplasminogenemia), leads to rare disorders such as ligneous conjunctivitis, characterized by pseudomembrane formation on mucosal surfaces and impaired wound healing. Therapeutically, plasminogen supplementation is used to treat plasminogen deficiency, and its activation pathway is targeted by thrombolytic drugs for conditions like stroke and myocardial infarction.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Biological Activity
>= 120 units per mg protein. One unit is defined as the amount of the enzyme which hydrolyzes one umole of N-tosyl-L arginine-methyl ester in 30 minutes at 37oC, pH 8.0.
Storage
For long term, store Human Plasminogen at ≤ -20°C.
Applications
In Vitro Diagnostics, Coagulation, Fibrinolysis, Complement System, Inflammation, Cancer, Stroke, Biotherapeutics, Cardiovasculsr Disease.
Citations/Publications
Li, W., et al., (2017), 'Stretching single fibrin fibers hampers their lysis', Acta Biomaterialia 60: pp 264–274. Available at: http://dx.doi.org/10.1016/j.actbio.2017.07.037
Contois, J. H., et al., (2024), 'Feasibility of a unique homogenous assay for lipoprotein(a) particle number without bias from apo(a) size isoforms', Clinical Chemistry, 70, (Supplement_1): hvae106.213. Available at: https://doi.org/10.1093/clinchem/hvae106.213
Singh, S., et al., (2016), 'Physiologic variations in blood plasminogen levels affect outcomes after acute cerebral thromboembolism in mice: a pathophysiologic role for microvascular thrombosis', J Thromb Haemost 14: pp 1822–32. Available at: DOI: 10.1111/jth.13390
Yang, W., et al., (2018), 'EPAC1 regulates endothelial annexin A2 cell surface translocation and plasminogen activation, ' FASEB J. 32: pp 2212–2222. Available at: doi: 10.1096/fj.201701027R
Shipped with ice packs
Gel Scan of Human Plasminogen
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
