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Human Prealbumin (Transthyretin)
Native, whole molecule
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Proteins Synonyms: PA, Transthyretin, Thyroxine Binding Prealbumin, ATTR, TBPA, TTR, PALB Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. Physical State: Lyophilized from 50 mM Na phosphate, pH 7.5, with 150 mM NaCl Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
PA, Transthyretin, Thyroxine Binding Prealbumin, ATTR, TBPA, TTR, PALB
Description of Human Prealbumin (Transthyretin)
Human Prealbumin (Transthyretin) is a 55 kDa protein. Prealbumin, also known as transthyretin, is a serum protein present in plasma at approximately 30 mg per 100 ml. Synthesized primarily in the liver, prealbumin plays a vital role in transporting thyroxine (T4), vitamin A, and retinol-binding protein throughout the bloodstream. Its structure allows it to form complexes with these molecules, facilitating their delivery to target tissues. Prealbumin has a short biological half-life of about two days, making it a sensitive marker for acute changes in nutritional status and protein-energy malnutrition. Clinically, low prealbumin levels are commonly observed in conditions such as viral hepatitis, cirrhosis, malnutrition, inflammation, acute kidney injury, and after surgical trauma. Decreased levels are associated with poor prognosis and increased mortality in critically ill and hospitalized patients. Prealbumin measurement is widely used to monitor nutritional interventions, assess liver function, and predict patient outcomes, especially in acute and chronic disease management.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Prealbumin (Transthyretin) at ≤ -20°C.
Applications
Inflammation, In Vitro Diagnostics, Cardiovascular.
Citations/Publications
Iino, T., et al., (2024), 'Assessment of transthyretin instability in patients with wild‑type transthyretin amyloid cardiomyopathy', Scientific Reports. 14: pp 20508. Available at: https://doi.org/10.1038/s41598-024-71446-8
Zheng, Y. Z., et al., (2017), 'Manipulating trypsin digestion conditions to accelerate proteolysis and simplify digestion workflows in development of protein mass spectrometric assays for the clinical laboratory', Clinical Mass Spectrometry 6: pp 1–12. Available at: https://doi.org/10.1016/j.clinms.2017.10.001
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02766/
Shipped with ice packs
Gel Scan of Human Prealbumin (Transthyretin)
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
