Human Retinol Binding Protein (RBP4)

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Product Overview, Sizes and Prices
	Proteins Synonyms: RBP4 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. Physical State: Lyophilized from 50 mM Tris, 100 mM NaCl, pH 7.4 Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-180216-100UG 100 µg 230 € 16-16-180216-1MG 1 mg 1.150 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

RBP4

 

Description of Human Retinol Binding Protein (RBP4)

Human Retinol Binding Protein (RBP4) is a 21 kDa protein. Retinol binding protein 4 (RBP4) is a member of the lipocalin family and serves as the primary transporter of retinol (vitamin A) in the bloodstream, present at about 40 mg/L in healthy individuals. Synthesized mainly in the liver, RBP4 binds retinol and forms a complex with transthyretin, which prevents its loss via kidney filtration and ensures efficient delivery of vitamin A to peripheral tissues. Beyond its canonical role in retinoid homeostasis, RBP4 functions as an adipokine and has been implicated in metabolic regulation. Elevated RBP4 levels are strongly associated with insulin resistance, obesity, type 2 diabetes, gestational diabetes, metabolic syndrome, and cardiovascular diseases, correlating with increased levels of APO B-containing lipoproteins such as LDL and VLDL. RBP4 can also trigger adipose tissue inflammation, linking it to chronic metabolic and inflammatory conditions. Clinically, RBP4 is under investigation as a biomarker for metabolic disorders and chronic kidney disease, and as a potential therapeutic target in diabetes and cardiovascular risk management.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Retinol Binding Protein (RBP4) at ≤ -20°C.

 

Applications

In Vitro Diagnostics, Diabetes, Inflammation, Cardiovascular Disease, Biotherapeutics.

 

Citations/Publications

Est., C. B., et al., (2020), 'Retinol binding protein IV purified from Escherichia coli using intein-mediated cleavage as a suitable replacement for serum sources', Protein Expression and Purification. 167: p 105542. Available at: https://doi.org/10.1016/j.pep.2019.105542
Zheng, Y. Z., et al., (2017), 'Manipulating trypsin digestion conditions to accelerate proteolysis and simplify digestion workflows in development of protein mass spectrometric assays for the clinical laboratory, ' Clinical Mass Spectrometry 6: pp 1–12. Available at: https://doi.org/10.1016/j.clinms.2017.10.001
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02753/

 

Shipped with ice packs

 

Gel Scan of Human Retinol Binding Protein (RBP4)

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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