EN
Human Rheumatoid Factor, Immunoglobulin M (RF - IgM)
Native whole molecule
Product Overview, Sizes and Prices | ||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteins Synonyms: RF-IgM Source: Human Plasma Purity: Elevation Level: 1000 to 2000 U/ml Physical State: Liquid in 20 mM Sodium Phosphate, pH 7.4, with 150 mM NaCl and 0.09% NaN3 Manufacturer: |
|
|||||||||||||||||||||||||||||||||
Athens Research & Technology
Produktdetails
Synonyms
RF-IgM
Description of Human Rheumatoid Factor, Immunoglobulin M (RF - IgM)
Human Rheumatoid Factor, Immunoglobulin M (RF - IgM) is a 970 kDa protein. Rheumatoid factor IgM (RF-IgM) is an autoantibody produced by the immune system that targets the Fc region of immunoglobulin G (IgG), forming immune complexes that can drive inflammation. RF-IgM is the most clinically significant and commonly measured isotype among rheumatoid factors, present in approximately 70–80% of patients with rheumatoid arthritis (RA). Functionally, RF-IgM amplifies inflammatory responses by increasing the recruitment of IgG into immune complexes, which then stimulate macrophages to secrete proinflammatory cytokines such as TNF-α, IL-6, and IL-8, and enhance complement activation, contributing to joint inflammation and tissue damage in RA. High levels of RF-IgM are associated with more severe, progressive disease, greater joint destruction, and increased risk of extra-articular manifestations. Beyond RA, RF-IgM can be elevated in other autoimmune diseases (e.g., Sjögren’s syndrome, systemic lupus erythematosus) and chronic infections (e.g., hepatitis C, endocarditis)2. Clinically, RF-IgM serves as a diagnostic and prognostic marker in RA and is used alongside anti-cyclic citrullinated peptide (anti-CCP) antibodies to improve diagnostic accuracy and guide disease management.
Source
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Storage
For long term, store Human Rheumatoid Factor, Immunoglobulin M (RF - IgM) at +2 to 8°C.
Applications
In Vitro Diagnostics, Autoimmune Disease, Rheumatoid Arthritis.
Citations/Publications
Sun, M., et al., (2019), 'Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts', Ann Rheum Dis 78: pp 1621–1631. Available at: doi:10.1136/annrheumdis-2018-214967
Ugolini, A., et al., (2020), 'IgM-Rheumatoid factor confers primary resistance to anti-PD-1 immunotherapies in NSCLC patients by reducing CD137+T-cells.', EBioMedicine 62: 103098. Available at: doi.org/10.1016/j.ebiom.2020.103098
Bharadwaj, P., et al., (2019), 'Implementation of a three-tiered approach to identify and characterize anti-drug antibodies raised against HIV-specific broadly neutralizing antibodies', Journal of Immunological Methods 479: pp 112764. Available at: https://doi.org/10.1016/j.jim.2020.112764
Shipped with ice packs
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
To buy Human Rheumatoid Factor, Immunoglobulin M (RF - IgM) please click on the Shopping List Symbol right from the indicated price. This will add Human Rheumatoid Factor, Immunoglobulin M (RF - IgM) to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.
For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
