Human Superoxide Dismutase

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	Proteins Synonyms: SOD, erythrocuprein, hemocuprein, cytocuprein, superoxide:superoxide oxidoreductase, Biological Activity: >50, 000 units/mg protein Source: Human Blood Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 0.1 M potassium phosphate, pH 7.5 Manufacturer:  Athens Research & Technology	Article No. Size Price   16-05-191504-100UG 100 µg 370 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

SOD, erythrocuprein, hemocuprein, cytocuprein, superoxide:superoxide oxidoreductase,

 

Description of Human Superoxide Dismutase

Human Superoxide Dismutase is a 16 kDa protein. Superoxide dismutase (SOD) is a critical antioxidant enzyme present in nearly all living cells exposed to oxygen. It catalyzes the rapid conversion of superoxide radicals-harmful byproducts of cellular metabolism-into hydrogen peroxide and molecular oxygen, thereby protecting cells from oxidative damage. SOD achieves this through highly efficient redox cycling at its active site, which contains essential metal cofactors such as copper, zinc, manganese, or iron, depending on the SOD isoform. These metal ions facilitate electron transfer, enabling SOD to neutralize superoxide radicals at rates limited only by molecular diffusion. Functionally, SOD plays a vital role in cellular defense against oxidative stress, maintaining metabolic and mitochondrial integrity. Mutations in the SOD1 gene are linked to familial amyotrophic lateral sclerosis (ALS), while altered SOD activity is implicated in diseases such as Parkinson’s, Alzheimer’s, Down syndrome, cardiovascular disease, and various inflammatory and neurodegenerative disorders. Clinically, SOD and its recombinant forms are being explored for therapeutic applications in conditions characterized by oxidative stress, including cardiovascular disease, traumatic brain injury, cancer, dermatological disorders, and inflammatory diseases. SOD activity is also used as a biomarker for oxidative stress and tissue health in both research and clinical diagnostics.

 

Source

Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

 

Biological Activity

>50, 000 units/mg protein. One unit is defined as the amount of enzyme which will inhibit by 50% the formation of a colorimetric indicator by O2 in a xanthine/xanthine oxidase coupled system.

 

Storage

For long term, store Human Superoxide Dismutase at ≤ -20°C.

 

Applications

Cell Culture Media, In Vitro Diagnostics, Oxidative Sstress, amyotrophic lateral sclerosis , Pakinson's, Alzheimer's, Cardiovascular Disease, Inflammation, Cancer.

 

Citations/Publications

NCBI: https://www.ncbi.nlm.nih.gov/protein/P00441/

 

Shipped with ice packs

 

Gel Scan of Human Superoxide Dismutase

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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