Human TIE-1 soluble / FC Chimera (InCs) recombinant Protein
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TIE1, TIE, JTK14
Description of Human TIE-1 soluble / FC Chimera (InCs)
Recombinant human soluble TIE-1 was fused with the Fc part of human IgG1. The soluble receptor protein consists of the full extracellular domain (Met1-Glu749). The recombinant mature TIE-1/Fc is a disulfide-linked homodimeric protein. Human TIE-1/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 125 kDa protein in SDS-PAGE under reducing conditions. TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], so far no ligand was found for TIE-1.
Bioassay data are not available.
Centrifuge vial prior to opening. The lyophilized sTIE-1-His is soluble in water and most aqueous buffers and should be reconstituted in PBS to a concentration not lower than 50µg/ml.
Amino Acid Sequence
VDLTLLANLR LTDPQRFFLT CVSGEAGAGR GSDAWGPPLL LEKDDRIVRT PPGPPLRLAR NGSHQVTLRG FSKPSDLVGV FSCVGGAGAR RTRVIYVHNS PGAHLLPDKV THTVNKGDTA VLSARVHKEK QTDVIWKSNG SYFYTLDWHE AQDGRFLLQL PNVQPPSSGI YSATYLEASP LGSAFFRLIV RGCGAGRWGP GCTKECPGCL HGGVCHDHDG ECVCPPGFTG TRCEQACREG RFGQSCQEQC PGISGCRGLT FCLPDPYGCS CGSGWRGSQC QEACAPGHFG ADCRLQCQCQ NGGTCDRFSG CVCPSGWHGV HCEKSDRIPQ ILNMASELEF NLETMPRINC AAAGNPFPVR GSIELRKPDG TVLLSTKAIV EPEKTTAEFE VPRLVLADSG FWECRVSTSG GQDSRRFKVN VKVPPVPLAA PRLLTKQSRQ LVVSPLVSFS GDGPISTVRL HYRPQDSTMD WSTIVVDPSE NVTLMNLRPK TGYSVRVQLS RPGEGGEGAW GPPTLMTTDC PEPLLQPWLE GWHVEGTDRL RVSWSLPLVP GPLVGDGFLL RLWDGTRGQE RRENVSSPQA RTALLTGLTP GTHYQLDVQL YHCTLLGPAS PPAHVLLPPS GPPAPRHLHA QALSDSEIQL TWKHPEALPG PISKYVVEVQ VAGGAGDPLW IDVDRPEETS TIIRGLNAST RYLFRMRASI QGLGDWSNTV EESTLGNGLQ AEGPVQETRS DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSREEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPMLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK
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