Human TIE-1 soluble / FC Chimera (InCs) recombinant Protein

Please log in to see the special conditions of your institution.

 

Phone: +49 (0) 40 . 43 20 84 48 0

E-Mail: info@active-bioscience.de

 

Product Overview, Sizes and Prices

 

Protein

Synonyms: TIE1, TIE, JTK14

Source: Insect cells

Purity: ≥ 90 % (SDS-PAGE, silver stained)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1950.952.020 20 µg 100 €
1950.952.100 100 µg 285 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

TIE1, TIE, JTK14

 

Description of Human TIE-1 soluble / FC Chimera (InCs)

Recombinant human soluble TIE-1 was fused with the Fc part of human IgG1. The soluble receptor protein consists of the full extracellular domain (Met1-Glu749). The recombinant mature TIE-1/Fc is a disulfide-linked homodimeric protein. Human TIE-1/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 125 kDa protein in SDS-PAGE under reducing conditions. TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], so far no ligand was found for TIE-1.

 

Biological Activity

Bioassay data are not available.

 

Reconstitution

Centrifuge vial prior to opening. The lyophilized sTIE-1-His is soluble in water and most aqueous buffers and should be reconstituted in PBS to a concentration not lower than 50µg/ml.

 

Amino Acid Sequence

VDLTLLANLR LTDPQRFFLT CVSGEAGAGR GSDAWGPPLL LEKDDRIVRT PPGPPLRLAR NGSHQVTLRG FSKPSDLVGV FSCVGGAGAR RTRVIYVHNS PGAHLLPDKV THTVNKGDTA VLSARVHKEK QTDVIWKSNG SYFYTLDWHE AQDGRFLLQL PNVQPPSSGI YSATYLEASP LGSAFFRLIV RGCGAGRWGP GCTKECPGCL HGGVCHDHDG ECVCPPGFTG TRCEQACREG RFGQSCQEQC PGISGCRGLT FCLPDPYGCS CGSGWRGSQC QEACAPGHFG ADCRLQCQCQ NGGTCDRFSG CVCPSGWHGV HCEKSDRIPQ ILNMASELEF NLETMPRINC AAAGNPFPVR GSIELRKPDG TVLLSTKAIV EPEKTTAEFE VPRLVLADSG FWECRVSTSG GQDSRRFKVN VKVPPVPLAA PRLLTKQSRQ LVVSPLVSFS GDGPISTVRL HYRPQDSTMD WSTIVVDPSE NVTLMNLRPK TGYSVRVQLS RPGEGGEGAW GPPTLMTTDC PEPLLQPWLE GWHVEGTDRL RVSWSLPLVP GPLVGDGFLL RLWDGTRGQE RRENVSSPQA RTALLTGLTP GTHYQLDVQL YHCTLLGPAS PPAHVLLPPS GPPAPRHLHA QALSDSEIQL TWKHPEALPG PISKYVVEVQ VAGGAGDPLW IDVDRPEETS TIIRGLNAST RYLFRMRASI QGLGDWSNTV EESTLGNGLQ AEGPVQETRS DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSREEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPMLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK

 

 

 

To buy Human TIE-1 soluble / FC Chimera (InCs) please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500 € within Germany

This website uses cookies to store your Personal Shopping List. By using our website you accept the use of session cookies. Learn more
Got it