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Human Transferrin (HOLO)
Native, whole molecule
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Proteins Synonyms: Trf, Siderophilin, Serotransferrin, Beta-1 metal-binding globulin, TRF, TF, PRO1400, PRO1557 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Iron Content: ≥1100 µg per gram Physical State: Lyophilized from 20 mM Na Phosphate, pH 7.4, and 150 mM NaCl Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
Trf, Siderophilin, Serotransferrin, Beta-1 metal-binding globulin, TRF, TF, PRO1400, PRO1557
Description of Human Transferrin (HOLO)
Human Transferrin (HOLO) is a 80 kDa protein. Transferrin is a multifunctional monomeric glycoprotein primarily synthesized in the liver and found abundantly in plasma, where it plays a central role in iron metabolism and homeostasis. Each transferrin molecule can reversibly bind two ferric (Fe³⁺) ions with high affinity, facilitating the safe transport and regulated distribution of iron from absorption sites in the gut and macrophages to tissues throughout the body, especially to the bone marrow for hemoglobin synthesis. This iron delivery is mediated through transferrin receptors on cell surfaces, enabling receptor-mediated endocytosis and precise cellular iron uptake. Beyond iron transport, transferrin possesses significant antimicrobial properties by sequestering free iron, thereby limiting its availability to bacteria and fungi-a process that contributes to innate immune defense and exhibits bacteriostatic and fungistatic effects. Clinically, altered transferrin levels are linked to various conditions: increases are seen in iron-deficiency anemia and pregnancy, while decreases occur in inflammatory diseases, nephrotic syndrome, hypoproteinemia, and rare genetic disorders like atransferrinemia, which causes severe anemia and iron overload in tissues. Transferrin’s applications extend to clinical diagnostics, where it serves as a biomarker for iron status and certain metabolic disorders, and to biotechnology, where it is an essential supplement in cell culture media for optimal cell growth. Additionally, transferrin and its receptor are being explored as targeted drug delivery vehicles, particularly for crossing the blood-brain barrier and treating central nervous system diseases.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Transferrin (HOLO) at -20°C.
Applications
ELISA, Antisera Production, In Vitro Diagnostic, Protein Chemistry Research, Drug Delivery research, Iron Metabolism, Infection.
Citations/Publications
Don., A., et al., (2021), '2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 b-thalassemia patient cells restoring hemoglobin A production and chain rebalance', Haematologica 106(5): pp 1433-1442. Available at: https://doi.org/10.3324/haematol.2019.226852
Choi, S. R., et al., (2021), 'Nanoparticulate β‐Cyclodextrin with Gallium Tetraphenylporphyrin Demonstrates in Vitro and in Vivo Antimicrobial Efficacy against Mycobacteroides abscessus and Mycobacterium avium', ACS Infect. Dis. 7: pp 2299−2309. Available at: https://doi.org/10.1021/acsinfecdis.0c00896
Dziuba, N., et al., (2019), 'Low-molecular-mass iron complexes in blood plasma of iron-deficient pigs do not originate directly from nutrient iron', Metallomics, 11: pp 1900. Available at: DOI:10.1039/c9mt00152b
Vali, S. W., et al., (2022), 'Might nontransferrin-bound iron in blood plasma and sera be a nonproteinaceous high-molecular-mass FeIII aggregate?', J. Biol. Chem. 298(12): pp 102667. Available at: https://doi.org/10.1016/j.jbc.2022.102667
Shang, Y., et al., (2016), 'Integrated Microfluidic Lectin Barcode Platform for High-Performance Focused Glycomic Profiling', Scientific Reports 6: pp 20297. Available at: DOI: 10.1038/srep20297
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02787/
Shipped with ice packs
Gel Scan of Human Transferrin (HOLO)
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
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