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Human Transferrin (HOLO), Bioprocessing Grade
Native, whole molecule, Bioprocessing Grade
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Proteins Synonyms: Trf, Siderophilin, Serotransferrin, Beta-1 metal-binding globulin, TRF, TF, PRO1400, PRO1557 Source: Human Plasma Purity: ≥ 98% by SDS-PAGE Endotoxin Level: < 1.0 EU/mg by LAL testing Iron Content: < 1200 – 1700 µg/g Physical State: Lyophilized from sterile de-ionized water after filtration using a sterile 0.1 micron filter. Heat treated at 60 °C for 10 hours. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
Trf, Siderophilin, Serotransferrin, Beta-1 metal-binding globulin, TRF, TF, PRO1400, PRO1557
Description of Human Transferrin (HOLO), Bioprocessing Grade
Human Transferrin (HOLO), Bioprocessing Grade is a 80 kDa protein. Transferrin is a multifunctional monomeric glycoprotein primarily synthesized in the liver and found abundantly in plasma, where it plays a central role in iron metabolism and homeostasis. Each transferrin molecule can reversibly bind two ferric (Fe³⁺) ions with high affinity, facilitating the safe transport and regulated distribution of iron from absorption sites in the gut and macrophages to tissues throughout the body, especially to the bone marrow for hemoglobin synthesis. This iron delivery is mediated through transferrin receptors on cell surfaces, enabling receptor-mediated endocytosis and precise cellular iron uptake. Beyond iron transport, transferrin possesses significant antimicrobial properties by sequestering free iron, thereby limiting its availability to bacteria and fungi-a process that contributes to innate immune defense and exhibits bacteriostatic and fungistatic effects. Clinically, altered transferrin levels are linked to various conditions: increases are seen in iron-deficiency anemia and pregnancy, while decreases occur in inflammatory diseases, nephrotic syndrome, hypoproteinemia, and rare genetic disorders like atransferrinemia, which causes severe anemia and iron overload in tissues. Transferrin’s applications extend to clinical diagnostics, where it serves as a biomarker for iron status and certain metabolic disorders, and to biotechnology, where it is an essential supplement in cell culture media for optimal cell growth. Additionally, transferrin and its receptor are being explored as targeted drug delivery vehicles, particularly for crossing the blood-brain barrier and treating central nervous system diseases.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Transferrin (HOLO), Bioprocessing Grade at -20°C.
Applications
Biomanufacturing, ELISA, Antisera Production, In Vitro Diagnostic, Protein Chemistry Research, Drug Delivery research, Iron Metabolism, Infection.
Citations/Publications
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02787/
Shipped with ice packs
Gel Scan of Human Transferrin (HOLO), Bioprocessing Grade
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
