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Murine Albumin
Native, whole molecule
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Proteins Synonyms: Alb Source: Mouse Plasma Physical State: Salt-free lyophilized solid Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
Alb
Description of Murine Albumin
Murine Albumin is a 66 kDa protein. Albumin constitutes 60% of plasma proteins and exhibits exceptional structural stability due to its 17 disulfide bonds and conserved N-glycosylation. Beyond maintaining 80% of plasma oncotic pressure to prevent vascular fluid leakage, albumin binds and transports hydrophobic ligands-including fatty acids, steroids, thyroid hormones, calcium ions, and over 90% of circulating drugs-via its dynamic binding pockets. Its free Cys34 residue confers antioxidant properties by scavenging reactive oxygen species. Hypoalbuminemia (<3.5 g/dL) arises from hepatic dysfunction (cirrhosis, hepatitis), renal protein loss (nephrotic syndrome), chronic inflammation, or malnutrition. Clinically, it manifests as edema, ascites, and impaired drug efficacy due to reduced ligand binding. Conversely, glycated albumin contributes to diabetic complications by promoting vascular endothelial dysfunction3. Therapeutically, human serum albumin (HSA) has been administered since 1941 for hypovolemia and burns, with modern 5% and 25% solutions managing ARDS and cardiopulmonary bypass. With a 19-day circulatory half-life, albumin stabilizes cell culture media.
Source
Mouse plasma was obtained from healthy animals of US origin and under the care of a registered veterinarian.
Storage
For long term, store Murine Albumin at ≤ -20°C.
Applications
Cell Culture Media, In Vitro Diagnostic, Calibrators, Control, Antisera Production, Protein Chemistry, Therapeutics Research.
Citations/Publications
Liu, H., et al., (2021), 'An engineered IL-21 with half-life extension enhances anti-tumor immunity as a monotherapy or in combination with PD-1 or TIGIT blockade', International Immunopharmacology 101: pp 108307. Available at: https://doi.org/10.1016/j.intimp.2021.108307
NCBI: https://www.ncbi.nlm.nih.gov/protein/P07724
Shipped with ice packs
Gel Scan of Murine Albumin
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
