Murine ESM-1 / Endocan His-Tag recombinant Protein
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Esm1, ESM-1, AV004503, 0610042H23Rik, endothelial cell-specific molecule 1.
Description of Murine ESM-1 / Endocan His-Tag
Endocan, also known as endothelial cell-specific molecule1 (ESM1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is up-regulated by TNFa, IL1ß or lipopolysaccharide and down-regulated by IFN?. The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte function-associated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM1 and reducing LFA1mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing Endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported.
Testing in Progress.
Mouse Endocan/ESM-1 should be reconstituted in water to a concentration of 0.1 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20 °C.
Amino Acid Sequence
WSAKYAVDCP EHCDKTECRS SLRCKRTVLD DCGCCQVCAA GPGETCYRTV SGMDGVKCGP GLKCHFYSEE DDFGDEFGIC KDCPYGTFGM ECKETCNCQS GICDRVTGRC LDFPFFQYAA AKSPSRTSAS HTERDSASGD GNAVREEIGE GNAARPSVMK WLNPRTRHHH HHH
Shipped at room temperature
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
To buy Murine ESM-1 / Endocan His-Tag please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Murine ESM-1 / Endocan His-Tag is an alternative for the no longer available Promokine ESM-1 (Endocan), mouse, recombinant (InC) (D-68375).
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