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Murine IFN-lambda-2 / IL-28A recombinant Protein
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Protein Synonyms: IFN-lambda-2, Interleukin-28A, IL-28A, Ifnl2, Il28a, EG330496. Source: E. coli Biological activity: ≥ 3.3 x 105 IU/mg Purity: ≥ 95% (SDS-PAGE, RP-HPLC) Physical state: Lyophilized Manufacturer: |
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Active Bioscience
Product Details
Synonyms
IFN-lambda-2, Interleukin-28A, IL-28A, Ifnl2, Il28a, EG330496.
Description of Murine IFN-lambda-2 / IL-28A
Recombinant Murine IFN-lambda-2 (IFN-?2) is a 19.7 kDa protein containing 174 amino acid residues. IFN-lambda-1, -2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas uses a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. (Kotenko, SV. Et al. Nat Immunology 2003 [1] p. 69-77).
Biological Activity
The ED50 of ≥ 3.3 × 105 IU/mg was determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis (EMC) virus is less than 3 ng/ml.
Reconstitution
We recommend a quick spin followed by reconstitution in sterile water to a concentration of at least 100 µg/ml, which can then be further diluted to other aqueous solutions. Do not vortex.
Stability
Lyophilized IFN-Lambda 2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IFN-Lambda 2 Recombinant should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA, order number: 2835.955.xyz or 2835.958.xyz, or BSA, order number: 2835.919.xyz). Please avoid repeated freeze-thaw cycles.
Amino Acid Sequence
DPVPRATRLP VEAKDCHIAQ FKSLSPKELQ AFKKAKDAIE KRLLEKDMRC SSHLISRAWD LKQLQVQERP KALQAEVALT LKVWENMTDS ALATILGQPL HTLSHIHSQL QTCTQLQATA EPKPPSRRLS RWLHRLQEAQ SKETPGCLED SVTSNLFRLL TRDLKCVASG DQCV
Shipped at room temperature
To buy Murine IFN-lambda-2 / IL-28A please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Murine IFN-lambda-2 / IL-28A is an alternative for the no longer available Promokine IFN-lambda-2 (IL28A), mouse, recombinant (D-60732).
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Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
