Murine TIE-2 soluble recombinant Protein
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Angiopoietin-1 receptor, Endothelial tyrosine kinase, HYK, STK1, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK, CD202b, Tek, Hyk, Tie2, AA517024
Description of Murine TIE-2 soluble
Recombinant mouse soluble TIE-2 was fused with a 6x His-tag at the C-terminus. The soluble receptor protein consists of the full extracellular domain (Ala23-Ala737). Mouse sTIE-2 monomer has a calculated molecular mass of approximately 79,86 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 95 kDa protein in SDS-PAGE under reducing conditions. TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis.
Testing under progress.
Centrifuge vial prior to opening. The lyophilized sTIE-2-His is soluble in water and most aqueous buffers and should be reconstituted in PBS or medium to a concentration not lower than 50µg/ml.
Amino Acid Sequence
AMDLILINSL PLVSDAETLT CIASGWHPHE PITIGRDFEA LMNQHQDPLE VTQDVTREWA KKVVWKREKA SKINGAYCEG RVRGQAIRIR TMKMRQQASF LPATLTMTVD RGDNVNISFK KVLIKEEDAV IYKNGSIHSV PRHEVPDILE VHLPHAQPQD AGVYSARYIG GNLFTSAFTR LIVRRCEAQK WGPDCRPCTT CKNNGVCHED TGECICPPGF MGRTCEKACE PHTFGRTCKE RCSGPEGCKS YVFCPDPYGC SCATGWRGLQ CNEACPSGYY GPDCKLRCHC TNEEICDRFQ GCLCSQGWQG LQCKEGRPRM TPQIEDLPDH IEVNSGKFNP ICKASGWPLP TSEEMTLVKP DGTVLQPNDF NYDRFSVAIF TVNRVLPPDS GVWVCSVNTV AGMVEKPFNI SVKVLPEPLH APNVIDTGHN FIINISSEPY FGDGPIKSKK LFYKPVNQAW KYIEVTNEIF TLNYLEPRTD YELCVQLARP EGGEGHPGPV RRFTTASIGL PPPRGLSLLP KSQTALNLTW QPIFTNSEDE FYVEVERRSQ TTSDQQNIKV PGNLTSVLLS NLVPREQYTV RARVNTKAQG EWSEELRAWT LSDILPPQEN IKISNITDST AMVSWTIVDG YSISSIIIRY KVQGKNEDQH IDVKIKNATV TQYQLKGEPE TTYHVDIFAE NNIGSSNPAF SHELRTLPHS PASATRHHHH HH
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