EN
Rat ApoTransferrin
Native, whole molecule
Product Overview, Sizes and Prices | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteins Synonyms: Apo indicates the Transferrin is free of Iron. Siderophilin, Serotransferrin, Beta-1 metal-binding globulin, ApoTRF, ApoTF Source: Rat Plasma Purity: ≥ 95% by SDS-PAGE Iron Content: < 30 µg/g Physical State: lyophilized from 20 mM NaH2PO4, pH 7.4, 150 mM NaCl Manufacturer: |
|
|||||||||||||||||
Athens Research & Technology
Produktdetails
Synonyms
Apo indicates the Transferrin is free of Iron. Siderophilin, Serotransferrin, Beta-1 metal-binding globulin, ApoTRF, ApoTF
Description of Rat ApoTransferrin
Rat ApoTransferrin is a 80 kDa protein. Apotransferrin, the iron-free form of the glycoprotein transferrin, serves as a critical regulator of systemic iron homeostasis by binding and transporting ferric ions (Fe³⁺) through plasma via a pH-dependent mechanism. It exhibits a structure with two iron-binding sites. Beyond its primary role in iron distribution, apotransferrin modulates immune function by sequestering free iron to limit microbial growth and directly suppresses proinflammatory cytokine production in autoimmune conditions like type 1 diabetes. Clinically, congenital atransferrinemia-caused by TF gene mutations-manifests as severe microcytic anemia coupled with tissue iron overload, requiring lifelong apotransferrin replacement therapy. In biotechnology, ultra-purified apotransferrin (<0.01% iron content, 1.25 µg/mg iron-binding capacity) serves as an essential cell culture supplement, facilitating iron uptake through transferrin receptor-mediated endocytosis while preventing oxidative stress. Recent applications exploit its targeting potential in nanoparticle drug delivery systems for cancer therapeutics and as an antimicrobial adjuvant to enhance antibiotic efficacy against Gram-negative pathogens. The protein's solubility (10 mg/ml in aqueous solutions) and stability under physiological conditions enable its use in diagnostic assays and bioreactor media for biopharmaceutical production.
Source
Rat plasma was obtained from healthy animals of US origin and under the care of a registered veterinarian.
Storage
For long term, store Rat ApoTransferrin at ≤ -20°C.
Applications
ELISA, Antigen for Antibody production, IVD Antigens, Calibrators & Controls, Protein Chemistry Research, Drug Delivery research.
Citations/Publications
NCBI: https://www.ncbi.nlm.nih.gov/protein/P12346
Shipped with ice packs
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
To buy Rat ApoTransferrin please click on the Shopping List Symbol right from the indicated price. This will add Rat ApoTransferrin to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.
For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
