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Rat Hemopexin
Native Whole Molecule
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Proteins Synonyms: HPX, HX, Beta-1B-glycoprotein Source: Rat Serum Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 11.9 mM phosphate, 137 mM NaCl, 2.7 mM KCl, pH 7.4. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
HPX, HX, Beta-1B-glycoprotein
Description of Rat Hemopexin
Rat Hemopexin is a 57 kDa protein. Hemopexin is a plasma glycoprotein with the highest known binding affinity for free heme, functioning as a critical scavenger during intravascular hemolysis or cellular injury. Structurally, it comprises two β-propeller domains that form a high-affinity heme-binding pocket, enabling it to neutralize heme's oxidative toxicity and facilitate its transport to the liver for iron recycling via CD163 receptors. As an acute-phase reactant, hemopexin synthesis increases during inflammation, though chronic hemolysis often depletes its levels, exacerbating tissue damage. Deficiencies or dysfunction in hemopexin are implicated in hemolytic anemias such as sickle cell disease and β-thalassemia, where unbound heme drives endothelial activation, vaso-occlusion, and organ damage. It also correlates with neurologic complications in familial epilepsy due to impaired heme clearance in neural tissues and contributes to sepsis-related mortality by failing to counteract hemoglobin-mediated inflammation. Therapeutically, hemopexin supplementation shows promise in preclinical models, reducing cardiovascular dysfunction in sickle cell mice by 50% and mitigating renal injury in hemolysis. It serves as both a biomarker for hemolytic severity and a potential therapeutic agent to attenuate heme toxicity in transfusion medicine, atherosclerosis, and acute porphyrias.
Source
Rat Serum used to purify Haptoglobin was obtained from healthy animals of US origin and under the care of a registered veterinarian.
Storage
For long term, store Rat Hemopexin at -20°C.
Applications
In Vitro Diagnostic, Glycosylation, Oxidative Damage, Lung Injury, Infection, Inflammation, Neurogenesis, Kidney Injury, Stroke, β-thalassemia, Sickle Cell Anemia, Epilepsy.
Citations/Publications
Zhang, P., et al., (2021), 'Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells', Front. Immunol. 12: pp 632709. Available at: doi:10.3389/fimmu.2021.632709
Vercellotti, G. M., et al., (2016), 'Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease', Molecular Medicine. 22: pp 437-451, 2016. Available at: doi: 10.2119/molmed.2016.00063
NCBI: https://www.ncbi.nlm.nih.gov/protein/P20059/
Shipped with ice packs
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
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