Rat IFN-gamma recombinant Protein

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Phone: +49 (0) 40 . 43 20 84 48 0

E-Mail: info@active-bioscience.de

 

Product Overview, Sizes and Prices

 

Protein

Synonyms: Immune IFN, type II IFN, T cell IFN, MAF, IFNG, IFG, IFI, IFN-gamma.

Source: E. coli

Biological activity: ≥ 1x107 units/mg

Purity: ≥ 95 % (SDS-PAGE, RP-HPLC)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1476.970.020 20 g 60 €
1476.970.100 100 g 159 €
1476.970.199 1 mg 890 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

Immune IFN, type II IFN, T cell IFN, MAF, IFNG, IFG, IFI, IFN-gamma.

 

Description of Rat IFN-gamma

Recombinant Rat IFN-gamma is a non-glycosylated 135 amino acid protein, with a molecular weight of 15,6 kDa. IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes activated by specific antigens, as well as activated NK cells. IFN-gamma receptors are present in most immune cells, which respond to IFN-gamma signaling by increasing the surface expression of MHC class I proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-gamma signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response. Additionally, IFN-gamma stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils.

 

Biological Activity

The ED50 of ≤ 0.1ng/ml was determined by a cytopathic inhibition assay with murine L929 cells challenged with EMC virus, corresponding to a specific activity of ≥ 1x107 units/mg.

 

Reconstitution

We recommend a quick spin followed by reconstitution water to a concentration of at least 100 g/ml. Do not vortex. This solution can be stored at 2-8C for up to 1 week or in working aliquots at -20C to -80C. Working aliquots should be at the highest practical concentration. For long term storage we recommend adding at least 0.1% HSA (order number: 2835.955.xyz or 2835.958.xyz) or BSA.

 

Stability

The lyophilized protein is stable at room temperature for up to 1 month and at least until the lot specific expiry date if kept below -18C. Reconstituted rat IFN-gamma stable for at least 3 months when stored in working aliquots at -20C to -80C with carrier protein. Please avoid repeated freeze thaw cycles.

 

Amino Acid Sequence

MQGTLIESLE SLKNYFNSSS MDAMEGKSLL LDIWRNWQKD GNTKILESQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT NFFSNSKAKK DAFMSIAKFE VNNPQIQHKA VNELIRVIHQ LSPESSLRKR KRSRC

 

 

 

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Errors, changes and availability excepted.

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500  within Germany

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