Rat IL-1 alpha recombinant Protein

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	Proteins Synonyms: Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF), IL-1 alpha,IL1, IL-1A, IL1F1. Source: E. coli Biological Activity: ≥ 2.0 x 108 IU/mg Purity: ≥ 98 % (SDS-PAGE, RP-HPLC) Physical State: Lyophilized Manufacturer:  Active Bioscience	Article No. Size Price   1495.970.002 2 µg 90 € 1495.970.010 10 µg 175 € 1495.970.199 1 mg 3.990 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF), IL-1 alpha,IL1, IL-1A, IL1F1.

 

Description of Rat IL-1 alpha

Recombinant Rat Interleukin-1 alpha (IL-1 alpha) is a 17.7 kDa protein consisting of 155 amino acid residues. Rat IL-1 alpha is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is a predominantly a cell-associated cytokine.

 

Biological Activity

The ED₅₀ of ≤ 0.005 ng/ml was determined by the dose-dependent stimulation of the proliferation of murine D10S cells. It corresponds to a specific activity of ≥ 2.0 x 10⁸ units/mg.

 

Reconstitution

We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.

 

Stability

The lyophilized protein is stable at room temperature for 3 weeks, but best stored desiccated below -18°C. Upon reconstitution IL1A should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA, order number: 2835.955.xyz or 2835.958.xyz, or BSA, order number: 2835.919.xyz). Please avoid repeated freeze-thaw cycles.

 

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Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-His-Ser-Phe.

 

Shipped at room temperature

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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