Rat Immunoglobulin G (IgG)

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	Proteins Synonyms: IgG, Immunoglobulin Gamma Source: Rat Serum Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3 Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-090707-RAT-10MG 10 mg 185 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

IgG, Immunoglobulin Gamma

 

Description of Rat Immunoglobulin G (IgG)

Rat Immunoglobulin G (IgG) is a 150 kDa protein. Immunoglobulin G (IgG), the most abundant plasma antibody (8–18 mg/mL), comprises four subclasses (IgG1–4) with distinct effector functions mediated by structural variations in their Fc regions. IgG neutralizes pathogens through Fab-mediated antigen binding and Fc-dependent mechanisms, including complement activation (via C1q binding to IgG1/IgG3) and antibody-dependent cellular cytotoxicity (ADCC) through FcγRIIIa engagement on natural killer cells. IgG’s extended half-life (21 days) arises from pH-dependent FcRn recycling, which also facilitates placental transfer, conferring neonatal immunity. Clinically, IgG deficiencies manifest as recurrent sinopulmonary infections: selective IgG subclass deficiencies (e.g., IgG2 impairing antipolysaccharide responses), while agammaglobulinemia features near-absent IgG (<200 mg/dL). Autoimmune disorders exhibit subclass-specific involvement-IgG4 drives MuSK myasthenia gravis through functional blockade, whereas IgG1/IgG3 mediate tissue damage in pemphigus via complement activation. Therapeutically, intravenous IgG (IVIG) at 2 g/kg modulates immunity in Guillain-Barré syndrome by Fc receptor saturation and anti-idiotypic effects. Diagnostic applications leverage IgG’s specificity in serological assays, with subclass profiling guiding immunodeficiency management.

 

Source

Rat serum was obtained from healthy animals of US origin.

 

Storage

For long term, store Rat Immunoglobulin G (IgG) at -20°C.

 

Applications

ELISA, In Vitro Diagnostic, Proteomics, Biotherapeutics.

 

Citations/Publications

Sun, X., et al., (2018), 'Identification and Characterization of Novel Fc-Binding Heptapeptides from Experiments and Simulations', Polymers 10: pp 778. Available at: doi:10.3390/polym10070778

 

Shipped with ice packs

 

Gel Scan of Rat Immunoglobulin G (IgG)

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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