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Rat Kallikrein
Native whole molecule
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Proteins Synonyms: KK, KLKB1, Kininogenase, Kininogenin, Fletcher factor, KLK3 Source: Rat Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 11.9 mM phosphate, 137 mM NaCl, 2.7 mM KCl, pH 7.4 Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
KK, KLKB1, Kininogenase, Kininogenin, Fletcher factor, KLK3
Description of Rat Kallikrein
Rat Kallikrein is a 87000 KDa protein. Kallikrein is a family of secreted serine proteases with diverse physiological roles, most notably in the generation of bradykinin, a potent vasodilator involved in regulating blood pressure, inflammation, and pain. In plasma, kallikrein exists as an inactive precursor called prekallikrein, which is synthesized in the liver and activated by factor XII during the intrinsic coagulation pathway. Upon activation, kallikrein cleaves kininogen to release bradykinin, thereby increasing vascular permeability and contributing to inflammatory responses. Structurally, kallikreins share a conserved catalytic triad essential for their proteolytic activity and are stabilized by multiple disulfide bridges. Clinically, dysregulation of kallikrein activity is implicated in hereditary angioedema (HAE), a rare genetic disorder characterized by episodes of severe swelling due to excessive bradykinin production. Kallikrein inhibitors are used therapeutically to manage HAE by blocking bradykinin release and preventing angioedema attacks. Additionally, kallikreins play roles in blood clotting, skin desquamation, and are being studied for their involvement in cancer, kidney function, and other inflammatory diseases.
Source
Prepared from Sprague-Dawley Rat Plasma taken from healthy animals with no signs of quarantinable or exotic disease housed at a USDA-licensed facility. Country of Origin: Rat plasma was obtained from healthy animals of US origin and under the care of a registered veterinarian.
Storage
For long term, store Rat Kallikrein at ≤ -80°C.
Applications
Inhibitor Assay, Rheumatoid Arthritis, Complement System, Diabetes, Hereditary Angioedema , Coagulation.
Citations/Publications
Teufel, D. P., et al., (2018), 'Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema', J. Med. Chem., 61(7), pp 2823–2836. Available at: https://doi.org/10.1021/acs.jmedchem.7b01625
NCBI: https://www.ncbi.nlm.nih.gov/protein/P14272
Shipped with dry ice
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
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