SARS-CoV-2 Spike Glycoprotein-S1 RBD (319-541, glycosylated, HEK, Fc-Tag) recombinant Protein
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Novel Coronavirus 2019 Glycoprotein-S1 Receptor Binding Domain (Amino Acid 319-541), recombinant
Description of SARS-CoV-2 Spike Glycoprotein-S1 RBD (319-541, glycosylated, HEK, Fc-Tag)
Recombinant Spike Glycoprotein S1 Receptor Binding Domain, derived from HEK293 cells is a glycosylated protein consisting of Amino acid 319-341, fused to Fc-Tag at the C-terminal. It is derived from the Wuhan-Hu-1 strain. SARS-CoV-2, formerly termed 2019-nCOV, causes the pandemic COVID-19 disease, a viral pneumonia. The production in HEK293 cells ensures the most authentic post translational modifications.
The SARS-CoV-2 shares an 87% identity to two bat-derived severe acute respiratory syndrome 2018 (SARS-like) coronaviruses found in Zhoushan of eastern China. It is more distant from SARS-CoV (79%) identity and MERS-CoV (50%) identity. SARS-CoV-2 has an analogous receptor-binding domain-structure to that of 2018 SARS-CoV, even though there is a.a. diversity so thus the 2019-nCoV might bind to ACE2 receptor protein (angiotensin-converting enzyme 2) in humans.
While bats are possibly the host of SARS-CoV, researchers suspect that animal from the ocean sold at the seafood market was an intermediate host. RSCU analysis proposes that the SARS-CoV-2 is a recombinant within the viral spike glycoprotein between the bat coronavirus and an unknown coronavirus.
We recommend a quick spin followed by reconstitution in water to a concentration of at least 100µg/ml, this solution can then be further diluted. Do not vortex.
The protein is stable until the lot specific expiry date if stored at -24°C or below. At room temperature it is stable for at least two weeks and to avoid repeated freeze thaw cycles we recommend short term (1-2 weeks) storage at 2°C - 4°C. Please avoid repeated freeze thaw cycles.
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