Human/Murine/Rat Activin A recombinant Protein

Bitte loggen Sie sich ein, um die Sonder­konditionen Ihrer Einrichtung zu sehen.

Synonyms

Inhba, Inhibin beta A, FSH releasing protein, Erythroid Differentiation Factor (EDF).

Description of Human/Murine/Rat Activin A

The active form of recombinant human Activin A is a 26.2 kDa disulfide-linked homodimer of two beta A chains, each containing 117 amino acid residues, belonging to the TGF-beta family. It exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, follistatin.

Biological Activity

The ED₅₀ of ≤ 1,5 ng/ml was determined by its ability to induce cytotoxicity of MPC-11 cell. It corresponds to a specific activity of ≥ 6 x 10⁵ U/mg.

Reconstitution

We recommend a quick spin followed by reconstitution in water to a concentration of 100µg/ml. This can be stored 4°C for 1 week or -20°C for future use. For long term storage we recommend to add a carrier protein (0.1% HSA, order number: 2835.955.xyz or 2835.958.xyz, or BSA, order number: 2835.919.xyz).

Stability

The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted Activin A should be stored in working aliquots at -20°C. Please avoid repeated freeze-thaw cycles.

vergrößern

Amino Acid Sequence

MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS

Shipped at room temperature

Download Datasheet