Human Vitronectin

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Produktübersicht, Größen und Preise
	Proteine Synonyms: VTN, VN, VTNC, S-protein, Serum-spreading factor, V75 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. Physical State: Lyophilized from 10 mM sodium phosphate, pH 7.7 Manufacturer:  Athens Research & Technology	Artikelnummer Größe Preis   16-16-220920-100UG 100 µg 255 € Bitte fragen Sie gerne nach anderen Größen und individuellen Abfüllungen.

 

 

Produktdetails

Synonyms

VTN, VN, VTNC, S-protein, Serum-spreading factor, V75

 

Description of Human Vitronectin

Human Vitronectin is a 65000 and 75000 Da protein. Vitronectin is a multifunctional glycoprotein abundantly present in blood plasma (200–400 µg/mL) and the extracellular matrix, where it plays key roles in cell adhesion, migration, tissue repair, and regulation of hemostasis. Acting as a scaffold, vitronectin supports cell attachment and spreading by binding to integrins such as αvβ3, and it is crucial for maintaining tissue integrity, wound healing, and skin regeneration. In the circulatory system, vitronectin interacts with plasminogen activator inhibitor-1 (PAI-1), stabilizing its active form and thereby regulating fibrinolysis and clot formation. This interaction is central to controlling blood coagulation, thrombosis, and wound healing, and also modulates cell migration and angiogenesis. Altered vitronectin levels or function are implicated in several diseases. Elevated vitronectin expression is associated with increased extracellular matrix deposition, contributing to conditions such as glaucoma and cardiac fibrosis. In cancer, particularly breast cancer, higher serum vitronectin levels correlate with increased metastasis and poorer survival, making it a promising non-invasive biomarker for early detection and prognosis. Vitronectin is also involved in immune regulation and may become depleted during disseminated intravascular coagulation and liver failure313. Clinically and in research, vitronectin is widely used as a substrate in cell culture to promote cell adhesion, proliferation, and survival, especially in stem cell and regenerative medicine applications. Its versatility in supporting cell growth and tissue repair, along with its diagnostic and therapeutic potential in cancer and fibrotic diseases, underscores vitronectin’s significance in both health and disease.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Vitronectin at -20°C.

 

Applications

Wound Healing, Cell Adhesion, Coagulation, Cancer, Cell Culture Media, Fibrinolysis, Glaucoma, Cardiac Fibrosis, In Vitro Diagnostic,.

 

Citations/Publications

Wihadmadyatami, H., et al., (2016), 'Immunisation against αIIbβ3 and αvβ3 in a type 1 variant of Glanzmann’s thrombasthenia caused by a missense mutation Gly540Asp on β3', Thrombosis and Haemostasis 116(2): pp 262-71. Available at: doi: 10.1160/TH15-12-0982.
Wihadmadyatami, H., et al., (2019), 'Ethanolic extract Ocimum sanctum Linn. induces an apoptosis in human lung adenocarcinoma (A549) cells', Heliyon 5: e02772. Available at: doi.org/10.1016/j.heliyon.2019.e02772 
Kusindarta, D. L., et al., (2016), 'Human umbilical mesenchymal stem cells conditioned medium promote primary wound healing regeneration', Veterinary World, 9(6): pp 605-610. Available at: doi: 10.14202/vetworld.2016.605-610
NCBI: https://www.ncbi.nlm.nih.gov/protein/P04004/

 

Shipped with ice packs

 

Gel Scan of Human Vitronectin

Fig. 1: SDS-PAGE Gel

 

 

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Verwendung: Nur für Forschungszwecke. Nicht zur Verwendung in diagnostischen oder therapeutischen Verfahren. Nicht für den menschlichen Gebrauch.

 

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