EN
Human Vitronectin
Native, whole molecule
Product Overview, Sizes and Prices | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteins Synonyms: VTN, VN, VTNC, S-protein, Serum-spreading factor, V75 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. Physical State: Lyophilized from 10 mM sodium phosphate, pH 7.7 Manufacturer: |
|
|||||||||||||
Athens Research & Technology
Produktdetails
Synonyms
VTN, VN, VTNC, S-protein, Serum-spreading factor, V75
Description of Human Vitronectin
Human Vitronectin is a 65000 and 75000 Da protein. Vitronectin is a multifunctional glycoprotein abundantly present in blood plasma (200–400 µg/mL) and the extracellular matrix, where it plays key roles in cell adhesion, migration, tissue repair, and regulation of hemostasis. Acting as a scaffold, vitronectin supports cell attachment and spreading by binding to integrins such as αvβ3, and it is crucial for maintaining tissue integrity, wound healing, and skin regeneration. In the circulatory system, vitronectin interacts with plasminogen activator inhibitor-1 (PAI-1), stabilizing its active form and thereby regulating fibrinolysis and clot formation. This interaction is central to controlling blood coagulation, thrombosis, and wound healing, and also modulates cell migration and angiogenesis. Altered vitronectin levels or function are implicated in several diseases. Elevated vitronectin expression is associated with increased extracellular matrix deposition, contributing to conditions such as glaucoma and cardiac fibrosis. In cancer, particularly breast cancer, higher serum vitronectin levels correlate with increased metastasis and poorer survival, making it a promising non-invasive biomarker for early detection and prognosis. Vitronectin is also involved in immune regulation and may become depleted during disseminated intravascular coagulation and liver failure313. Clinically and in research, vitronectin is widely used as a substrate in cell culture to promote cell adhesion, proliferation, and survival, especially in stem cell and regenerative medicine applications. Its versatility in supporting cell growth and tissue repair, along with its diagnostic and therapeutic potential in cancer and fibrotic diseases, underscores vitronectin’s significance in both health and disease.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Vitronectin at -20°C.
Applications
Wound Healing, Cell Adhesion, Coagulation, Cancer, Cell Culture Media, Fibrinolysis, Glaucoma, Cardiac Fibrosis, In Vitro Diagnostic,.
Citations/Publications
Wihadmadyatami, H., et al., (2016), 'Immunisation against αIIbβ3 and αvβ3 in a type 1 variant of Glanzmann’s thrombasthenia caused by a missense mutation Gly540Asp on β3', Thrombosis and Haemostasis 116(2): pp 262-71. Available at: doi: 10.1160/TH15-12-0982.
Wihadmadyatami, H., et al., (2019), 'Ethanolic extract Ocimum sanctum Linn. induces an apoptosis in human lung adenocarcinoma (A549) cells', Heliyon 5: e02772. Available at: doi.org/10.1016/j.heliyon.2019.e02772
Kusindarta, D. L., et al., (2016), 'Human umbilical mesenchymal stem cells conditioned medium promote primary wound healing regeneration', Veterinary World, 9(6): pp 605-610. Available at: doi: 10.14202/vetworld.2016.605-610
NCBI: https://www.ncbi.nlm.nih.gov/protein/P04004/
Shipped with ice packs
Gel Scan of Human Vitronectin
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
To buy Human Vitronectin please click on the Shopping List Symbol right from the indicated price. This will add Human Vitronectin to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.
For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
