Human ACE2 (glycosylated, HEK, His-Tag) Enzyme

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Product Overview, Sizes and Prices

 

Enzymes

Synonyms: Human Angiotensin Converting Enzyme 2 (a.a. 18-740), recombinant.

Source: HEK

Biological activity: 2 µg/ml, see below

Purity: ≥ 95% (SDS-PAGE)

Physical state: Sterile filtered, liquid

Manufacturer:  Active Bioscience

Article No. Size Price  
4575.955.050 50 µg 900 €
4575.955.150 150 µg 2.250 €
4575.955.250 250 µg 3.000 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

Human Angiotensin Converting Enzyme 2 (a.a. 18-740), recombinant.

 

Description of Human ACE2 (glycosylated, HEK, His-Tag)

Recombinant Human ACE2 is a glycosylated Enzyme derived from HEK cells consisting of Amino Acids 18-740. It is fused to a His-Tag at the N-terminus. ACE2 Protein binds to SARS Coronavirus-2 (nCoV-2019) Spike receptor binding domain. It is an entry receptor of SARS coronaviruses as well as SARS-CoV-2. ACE2 is the coronavirus spike (S) glycoprotein is a class I viral fusion antigen located on the external envelope of the virion that takes part in a critical part in viral infection by identifying host cell receptors and facilitating fusion of the viral and cellular membranes. 2 main domains in coronavirus S1 have been recognized, the N-terminal domain and C-terminal domain. One or the other and/or both S1 domains function as a receptor-binding domain. SARS-CoV + MERS-CoV equally use C-domain to attach their receptors. ACE2 is a type I transmembrane antigen with an extracellular N-terminal domain having the catalytic site and an intracellular C-terminal tail. ACE2 obtains a signal peptide, a transmembrane domain, and a single metalloproteinase active site containing an HEXXH zinc-binding domain. ACE-2 (Angiotensin converting enzyme 2) an enzyme bound to cell membranes in various organs such as intestines arteries, lungs, heart & kidney. ACE-2 plays a role as a mono-carboxypeptidase which degrades Ang I to produce the nonapeptide Ang 1–9 and Ang II to create the heptapeptide Ang 1–7.

 

Biological Activity

At 2µg/ml immobilized recombinant human ACE2 binds to SARS-CoV-2 Spike Protein Receptor Binding Domain in a functional ELISA.

 

Stability

The protein is stable for at least 2 weeks at 0°C - 4°C, and therefore can be shipped on ice packs. Upon arrival it should be stored at -20 °C. Please avoid repeated freeze thaw cycles.

 

Shipping symbol Shipped with ice packs

 

 

 

 

 

 

 

 

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Errors, changes and availability excepted.

 

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500 € within Germany

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