Human Apolipoprotein AI (ApoA1-LEL), Low Endotoxin Level

1. Home
2. Proteins
3. Human Proteins

Product Overview, Sizes and Prices
	Proteins Synonyms: ApoAI, ApoA1 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Endotoxin Level: ≤1 EU/mg Physical State: Frozen in 10 mM NH4HCO3, pH 7.4 Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-120101-LEL-500UG 500 µg 210 € 16-16-120101-LEL-1MG 1 mg 355 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

ApoAI, ApoA1

 

Description of Human Apolipoprotein AI (ApoA1-LEL), Low Endotoxin Level

Human Apolipoprotein AI (ApoA1-LEL), Low Endotoxin Level is a 28 kDa protein. Apolipoprotein AI (Apo AI), constituting 75% of HDL-associated apolipoproteins, is a critical for reverse cholesterol transport (RCT), mediating cholesterol efflux from peripheral tissues to the liver. As the primary structural component of HDL, Apo AI stabilizes discoidal HDL particles, activates lecithin-cholesterol acyltransferase (LCAT) to esterify cholesterol, and facilitates HDL maturatioN. Its anti-inflammatory properties include blocking T-cell–monocyte interactions, reducing TNF-α and IL-1β production, and neutralizing oxidized LDL. Normal plasma levels range from 90–130 mg/100 mL, with concentrations inversely correlating with coronary heart disease (CHD) risk. Deficiencies in Apo AI underlie Tangier disease, characterized by near-absent HDL, cholesterol-laden macrophages, and premature atherosclerosis. Mutations like APOA1 p.Leu202Arg cause systemic amyloidosis, leading to cardiac and renal dysfunction. Reduced Apo AI levels also associate with insulin resistance, impaired β-cell function, and diabetes progression. Conversely, Apo AI overexpression enhances macrophage-specific RCT, attenuating atherosclerosis.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Apolipoprotein AI (ApoA1-LEL), Low Endotoxin Level at -80°C.

 

Applications

In Vitro Diagnostic, Cardiovascular Research, ALS, Diabetes, Cell Based Assays, Animal Studies.

 

Citations/Publications

Deng, M. et al., (2018), 'LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration', Nature, 562: pp 605–609. Available at: https://doi.org/10.1038/s41586-018-0615-z
Garbuzova-Davis, et al., (2022), 'Apolipoprotein A1 Enhances Endothelial Cell Survival in an In Vitro Model of ALS', eNeuro, 9(4): ENEURO.0140-22.2022. Available at: DOI: 10.1523/ENEURO.0140-22.2022
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02647

 

Shipped with dry ice

 

Gel Scan of Human Apolipoprotein AI (ApoA1-LEL), Low Endotoxin Level

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

To buy Human Apolipoprotein AI (ApoA1-LEL), Low Endotoxin Level please click on the Shopping List Symbol right from the indicated price. This will add Human Apolipoprotein AI (ApoA1-LEL), Low Endotoxin Level to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

 

For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.