EN
Human Apolipoprotein AIV
Delipidated whole molecule, immunogen grade
Product Overview, Sizes and Prices | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteins Synonyms: ApoAIV, ApoA4 Source: Human Plasma Purity: ≥ 85% by SDS-PAGE ; immunoreactive by Western Blot to antisera to human apolipoprotein A4 Physical State: Frozen in 1 mM NH4HCO3, pH 8.2 Manufacturer: |
|
|||||||||||||
Athens Research & Technology
Produktdetails
Synonyms
ApoAIV, ApoA4
Description of Human Apolipoprotein AIV
Human Apolipoprotein AIV is a 46 kDa protein. Apolipoprotein A-IV (ApoA-IV), a glycoprotein synthesized predominantly in the small intestine during fat absorption, is a structural component of HDL and chylomicrons. Its four-helix bundle architecture facilitates lipid emulsification and interaction with apolipoprotein B (apoB) to promote chylomicron assembly and secretion. Postprandially, ApoA-IV dissociates from chylomicrons into the lipoprotein-free plasma fraction, where it activates lecithin-cholesterol acyltransferase (LCAT) and enhances lipoprotein lipase (LPL) activity via apoC-II, critical for triglyceride-rich lipoprotein catabolism. ApoA-IV exhibits protective roles against cardiovascular disease (CVD) by inhibiting vascular inflammation through NF-κB suppression and upregulating DHCR24, an anti-inflammatory enzyme. Genetic variants like APOA4 S347 correlate with elevated coronary heart disease (CHD) risk and reduced plasma ApoA-IV levels. In metabolic regulation, ApoA-IV improves insulin sensitivity by stimulating GLUT4 translocation in adipocytes via PI3K-Akt pathways and enhances glucose-stimulated insulin secretion, with deficiencies linked to glucose intolerance. Chronic high-fat diets blunt its satiety signaling, contributing to obesity, while Roux-en-Y gastric bypass increases ApoA-IV, correlating with weight loss and improved glucose control56. Clinically, ApoA-IV serves as a biomarker for CHD risk and diabetes progression. Therapeutic strategies targeting its anti-inflammatory, insulinotropic, and lipid-modulating properties show promise for metabolic and cardiovascular disorders.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Apolipoprotein AIV at -80°C.
Applications
Cardiovascular Research, Diabetes Research, In Vitro Diagnostic.
Citations/Publications
Deng, M. et al., (2018), 'LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration', Nature, 562: pp 605–609. Available at: https://doi.org/10.1038/s41586-018-0615-z
NCBI: https://www.ncbi.nlm.nih.gov/protein/P06727
Shipped with dry ice
Gel Scan of Human Apolipoprotein AIV
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
To buy Human Apolipoprotein AIV please click on the Shopping List Symbol right from the indicated price. This will add Human Apolipoprotein AIV to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.
For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
